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New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi trypanothione reductase



New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi trypanothione reductase



Bioorganic and Medicinal Chemistry 5(7): 1249-1256



Several spermine and spermidine derivatives containing 2-amino diphenylsulfide substituents were prepared and tested for their inhibiting effects on Trypanosoma cruzi trypanothione reductase. IC50 values were assessed between 0.3 and 3 microM. Compound 32 (Ki = 0.4 microM) is the most potent TR inhibitor described so far.

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Accession: 046799518

Download citation: RISBibTeXText

PMID: 9377084

DOI: 10.1016/s0968-0896(97)00070-9


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