EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Nutritionally induced insulin resistance and receptor defect leading to beta-cell failure in animal models


, : Nutritionally induced insulin resistance and receptor defect leading to beta-cell failure in animal models. Annals of the New York Academy of Sciences 892: 223-246

Animals with genetically or nutritionally induced insulin resistance and Type 2 diabetes comprise two groups: those with resilient beta-cells, e.g., ob/ob mice or fa/fa rats, capable of longstanding compensatory insulin hypersecretion and those with labile beta-cells in which the secretion pressure leads to beta-cell degranulation and apoptosis, e.g., db/db mice and Psammomys gerbils (sand rats). Psammomys features low insulin receptor density; on a relatively high energy diet it becomes hyperinsulinemic and hyperglycemic. In hyperinsulinemic clamp the hepatic glucose production is only partially suppressed by insulin, even in the normoglycemic state. The capacity of insulin to activate muscle and liver receptor tyrosine kinase is nearly abolished. GLUT4 content and mRNA are markedly reduced. Hyperinsulinemia was also demonstrated to inhibit insulin signaling and glucose transport in several other species. Among the factors affecting the insulin signaling pathway, phosphorylation of serine/threonine appears to be the prominent cause of receptor malfunction as inferred from the finding of overexpression of PKC epsilon isoforms in the muscle and liver of Psammomys. The insulin resistance syndrome progressing in animals with labile beta-cells to overt diabetes and beta-cell failure is a "thrifty gene" characteristic. This is probably also true for human populations emerging from food scarcity into nutritional affluence, inappropriate for their metabolic capacity. Thus, the nutritionally induced hyperinsulinemia, associated with PKC epsilon activation may be looked upon from the molecular point of view as "PKC epsilon overexpression syndrome."

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 046840348

PMID: 10842665

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Pledger, W.J.; Umbarger, H.E., 1973: Isoleucine and valine metabolism in Escherichia coli. XXI. Mutations affecting derepression and valine resistance. The activity of acetohydroxy acid isomeroreductase, an essential enzyme for isoleucine and valine biosynthesis in Escherichia coli, was examined in a series of mutants containing derepressed levels of acetohydroxy acid synthetase activity but whic...

Tatsumi N., 1981: Alterations of saponin hemolysis during storage of acid citrate dextrose blood. A dynamic hemolysis curve was examined on stored ACD [acid-citrate-dextrose] blood by a new instrument (mean cell volume or MCV continuous analyzer) during treatment with either saponin or with hypotonic medium. Several changes of the dynamic hemo...

KAMIN, H.; HANDLER, P., 1952: Effect of presence of other amino acids upon intestinal absorption of single amino acids in the rat. Amino acids were 1st admd. singly, and then re-admd. in the presence of an excess of a competing amino acid. The specific effects of the competing amino acids, previously noted in the kidney, were absent in the intestine. Amino acid absorption may...

Yoon, I., 1997: Surgical clip with ductile tissue penetrating members. Official Gazette of the United States Patent & Trademark Office Patents 1197(3): 1739, April 15

Gerowitt, B., 2003: Development and control of weeds in arable farming systems. It is investigated, whether the arable weed vegetation can perform as a characteristic to stimulate sustainable development of agriculture in Central Europe. The concept of sustainable development represents a dynamic process, influenced by ecolog...

Prasad, S.; Yashwant Singh; Singh, R. P.; Singh, G., 2005: Effect of crop establishment, weed control method and time of nitrogen application on late sown wheat. A study was conducted during the rabi seasons of 2000-01 and 2001-02 to determine the impact of zero tillage (ZT) in reducing the turn-around time and herbicides for weed control and suitable times of N application in wheat cv. HUW-234. Treatments...

Bowman, W.D., 2001: Perspectives on being a wilderness physician: is wilderness medicine more than a special body of knowledge?. Wilderness & Environmental Medicine 12(3): 165-167

Hughes, R.N.; Otto, M.T., 2013: Anxiolytic effects of environmental enrichment attenuate sex-related anxiogenic effects of scopolamine in rats. In groups of four same-sexed animals, PVG/c hooded rats were housed for 4.5 months in standard or enriched cages containing several objects that could be explored and manipulated. On separate occasions, each rat then experienced two consecutive da...

Neuber, A.E.; Van Den Broek, A.H.M.; Rhind, S.M.; Hill, P.B.; Thoday, K.L., 2006: Generalized alopecic and cystic dermatosis in a cat: a counterpart to the hairless mouse phenotype or a unique congenital dermatosis?. A 2-year-old, male neutered, domestic semi-long-haired cat was presented with a 1.5-year history of progressive, initially nonpruritic alopecia and malodorous greasy exudate affecting the distal extremities, trunk and neck but sparing the head and...

Stur, Johann, 1931: Zur Geschichte der Zeugungs-probleme. A Byzantine physician of the 11th century, Michael Psellos, has left a discussion of the problems of conception and embryology, here given in the original Greek and in a parallel German translation.