+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Opposite effects of stress on dopamine release in the limbic system of drug-naive and chronically amphetamine-treated rats

Opposite effects of stress on dopamine release in the limbic system of drug-naive and chronically amphetamine-treated rats

European Journal of Pharmacology 337(2-3): 219-222

The effects of repeated amphetamine administration on stress-induced dopamine release in the ventral striatum were examined in male Wistar rats treated with D-amphetamine (1.5 mg/kg; i.p./injection) or saline at 12 h intervals for 14 days. After 12 h as well as 7 days of amphetamine withdrawal, dopamine release was monitored by transverse microdialysis under basal conditions and during exposure to 60 min of restraint stress. Basal dopamine release was significantly suppressed relative to saline-pretreated controls after both 12 h and 7 days of amphetamine withdrawal. In control rats, restraint stress resulted in significantly increased dopamine efflux. In contrast, exposure to this stressor was associated with a significant suppression of dopamine release in rats chronically exposed to amphetamine. This effect was observed at both post-amphetamine test points. The results suggest that chronic amphetamine impairs the dopaminergic response to stress and that this dopaminergic deficit may play a role in stress-induced drug-seeking behavior and relapse.

(PDF emailed within 1 workday: $29.90)

Accession: 046870431

Download citation: RISBibTeXText

PMID: 9430417

Related references

Opposite effects of stress on dopamine release in the limbic system of drug-naive and chronically amphetamine-treated rats. European Journal of Pharmacology 337(2-3): 219-222, Oct 22, 1997

A comparison of some behavioral effects of amphetamine and electrical brain stimulation of the meso limbic dopamine system in rats. Psychopharmacology 75(2): 184-192, 1981

Parker and radow test of drug withdrawal aversion opposite effect in rats chronically infused with sufentanil of amphetamine. Pharmacology Biochemistry & Behavior 35(1): 219-224, 1990

Cocaine and amphetamine preferentially stimulate glutamate release in the limbic system: studies on the involvement of dopamine. Synapse 27(2): 95-105, 1997

The effects of footshock stress on regional brain dopamine metabolism and pituitary beta-endorphin release in rats previously sensitized to amphetamine. Neuropharmacology 26(7a): 679-691, 1987

Dopamine d1 and d2 agonists have opposite effects on striatal dopamine release in developing rats. Society for Neuroscience Abstracts 16(1): 341, 1990

Effects of ceruletide on perioral movements and the dopamine receptor-adenylate cyclase system in rats chronically treated with fluphenazine. Psychopharmacology. 125(3): 185-194, 1996

Differential up regulation of d 1 and d 2 dopamine receptor function in mesostriatal areas but not in cortical limbic brain regions of rats chronically treated with levo sulpiride and sch 23390. Drug Development Research 11(3-4): 243-250, 1987

The effects on blood pressure heart rate and behavior of chronically administered dopamine into the limbic system. Federation Proceedings 38(3 PART 1): 858, 1979

Effects of ceruletide on the dopamine receptor-adenylate cyclase system in striatum and frontal cortex of rats chronically treated with haloperidol. Psychopharmacology. 110(4): 383-389, 1993

Effects of lsd 2 5 di methoxy 4 methyl amphetamine and dextro amphetamine on operant responding in control and 6 hydroxy dopamine treated rats. Pharmacology Biochemistry & Behavior 13(5): 621-626, 1980

Differential effects of dextro amphetamine beta phenethylamine cocaine and methylphenidate on the rate of dopamine synthesis in terminals of nigro striatal and meso limbic neurons and on the efflux of dopamine metabolites into cerebro ventricular perfusates of rats. Life Sciences 33(19): 1899-1908, 1983

Enhanced stimulant effects of d-amphetamine in rats treated chronically with reserpine. Journal of Pharmacology and Experimental Therapeutics 163(1): 75-83, 1968

Biochemical effects induced by REM sleep deprivation in naive and in D-amphetamine treated rats. Neurobiology 6(1): 13-22, 1998