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Opposite effects on feeding of suprachiasmatic nucleus neuropeptide Y administration in rats

Opposite effects on feeding of suprachiasmatic nucleus neuropeptide Y administration in rats

Peptides 20(5): 601-609

The effects of injecting or infusing neuropeptide Y (NPY) into the suprachiasmatic nucleus of rats on patterns of individual macronutrient and water intake were examined during the following 2 h and also across 12 and 24 h light/dark cycles. Increased total energy intake (218 and 170%) and energy intake from the dextrin/sucrose diet (499 and 247%) were observed in the 2 h following injection of 100 pmol NPY at early light and early dark, respectively, and in the following 24 h (total energy: 67%, dextrin/sucrose: 73%). Nocturnal casein energy intake was also increased (258%) following NPY injection. Continuous infusion of 10 pmol/h of NPY suppressed nocturnal total energy (36%) and dextrin/sucrose intake (36%) as well as 24 h energy intake from casein (43%). These results demonstrate divergent effects of NPY subsequent to different mode of administration.

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Accession: 046870442

Download citation: RISBibTeXText

PMID: 10465512

DOI: 10.1016/s0196-9781(99)00013-3

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