+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Opposite influence of carbohydrates and fat on hypothalamic neurotensin in Long-Evans rats

Opposite influence of carbohydrates and fat on hypothalamic neurotensin in Long-Evans rats

Life Sciences 59(4): 349-356

Neurotensin inhibits food intake when injected in the central nervous system and is released after fat ingestion. The aim of the present study was to measure it in different brain areas and to determine if it is involved in the long-term variations in food intake induced by the ingestion of a high-fat (HF) diet. We compared the results with those obtained with 2 low-fat [high-carbohydrates (HC)] diets and a well-balanced diet. For this purpose, weanling male Long-Evans rats were fed ad libitum for 14 weeks either on a control diet, a HF diet or a HC diet. The rats with the HC (high-starch) diet were divided into 2 subgroups: the first (HC) drank water and the second (HCS) drank a 25% sucrose solution. During the last week of the experiment, energy intake of the HCS rats was significantly greater than that of the 3 other groups of rats (+17.2%; p < 0.01; +27.1%; p < 0.001 and +34.6%; P < 0.001 vs the control, HC and HF rats respectively). NT did not vary in the midbrain and particularly in the ventral tegmental area. Its concentrations were significantly higher in the 2 HC groups than in the HF rats both in the paraventricular (PVN; p < 0.02) and dorsomedial nuclei (DMN; p < 0.03). In the DMN, they were positively correlated with energy intake (r = 0.39; p = 0.027). These results indicate that hypothalamic neurotensin is indeed involved in the long-term modulation of feeding behavior by diet composition and that fat is the more potent macronutrient for its regulation.

(PDF emailed within 0-6 h: $19.90)

Accession: 046870448

Download citation: RISBibTeXText

PMID: 8761007

DOI: 10.1016/0024-3205(96)00304-9

Related references

Plasma ADH in normal Long-Evans rats and in Long-Evans rats heterozygous and homozygous for hypothalamic diabetes insipidus. Life Sciences 17(8): 1307-1314, 1975

Mechanisms of regional hemodynamic effects of neurotensin in normotensive long evans rats. Clinical & Investigative Medicine 15(4 SUPPL): A68, 1992

Mechanisms contributing to the regional haemodynamic effects of neurotensin in conscious, unrestrained Long Evans rats. British Journal of Pharmacology 105(1): 191-201, 1992

Conditioned locomotor activity following repeated intermittent activation of neurotensin receptors Comparison between Fischer 344, Lewis, and Long Evans rats. Society for Neuroscience Abstracts 27(1): 245, 2001

Comparison of the disposition behavior of organic anions in an animal model for Wilson's disease (Long-Evans Cinnamon rats) with that in normal Long-Evans Agouti rats. Drug Metabolism and Pharmacokinetics 19(2): 150-154, 2004

Hypothalamic neuropeptide Y regulation may be independent of energy intake in Long-Evans rats. Society for Neuroscience Abstracts 19(1-3): 1264, 1993

Suppression of QRFP 43 in the hypothalamic ventromedial nucleus of Long-Evans rats fed a high-fat diet. Biochemical and Biophysical Research Communications 383(1): 78-82, 2009

Neuroadaptation of hypothalamic gene expression in female long evans rats following chronic ethanol self-administration. Society for Neuroscience Abstracts 26(1-2): Abstract No -582 9, 2000

Cardiovascular actions of neuropeptide Y in the hypothalamic paraventricular nucleus of conscious Long Evans and Brattleboro rats. Neuroscience Letters 85(2): 239-243, 1988

Effects of lateral hypothalamic lesion with the neurotoxin hypocretin-2-saporin on sleep in Long-Evans rats. Neuroscience 116(1): 223-235, 6 January, 2003

Macronutrient type independently of energy intake modulates hypothalamic neuropeptide Y in Long-Evans rats. Brain Research Bulletin 34(2): 85-91, 1994

Plasma leptin and hypothalamic neuropeptide Y and galanin levels in Long-Evans rats with marked dietary preferences. Nutritional Neuroscience 4(1): 39-50, 2002

Chronic ethanol self-administration in female long evans rats imparts neuroadaptive changes in hypothalamic gene expression profiles. Alcoholism Clinical & Experimental Research 27(5 Supplement): 124A, 2003

Hypothalamic orexigenic peptides are overexpressed in young Long-Evans rats after early life exposure to fat-rich diets. Biochemical and Biophysical Research Communications 342(2): 452-458, 2006

Susceptibility to lung carcinogenesis in F344, Long-Evans Cinnamon and Long-Evans Agouti rats. Proceedings of the American Association for Cancer Research Annual Meeting 43: 169-170, 2002