+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Optic neuritis. A common first manifestation of multiple sclerosis

Optic neuritis. A common first manifestation of multiple sclerosis

Ugeskrift for Laeger 158(10): 1353-1357

Acute monosymptomatic optic neuritis (ON) may be regarded as a specific disease entity, or ON may be viewed as a first manifestation of multiple sclerosis (MS) representing one end of a continuum with fully developed clinically definite MS at the other end. To clarify this, the literature is reviewed, and the relationship between ON and MS is exemplified by examination of a cohort of 50 untreated representative patients with relevant paraclinical tests at onset of monosymptomatic ON. MRI, neurophysiological examinations and CSF analyses are supplementary methods, which together provide evidence that monosymptomatic ON is usually an early manifestation of MS, both being associated with the HLA tissue type DR15. The frequent finding of unenhanced lesions on MRI probably signify that the disease process may start long before the symptoms of ON. CSF may not be representative of the pathological processes in the CNS. Bilateral ON is not particularly liable to herald MS. More attention should be paid to subtle visual disturbances, which may indicate a new attack. It is important that more sensitive evaluations than merely assessing visual acuity be performed in these patients.

(PDF emailed within 1 workday: $29.90)

Accession: 046870861

Download citation: RISBibTeXText

PMID: 8644380

Related references

The Most/Common Eye Manifestation in Multiple Sclerosis: Optic Neuritis. Insight 41(3): 5-8, 2016

Optic neuritis, the most common initial presenting manifestation of multiple sclerosis in northern Iran. Caspian Journal of Internal Medicine 6(3): 151-155, 2015

Optic neuritis as the initial manifestation of multiple sclerosis. Klinika Oczna 102(2): 95-98, 2000

Optic neuritis in the childhood first clinical manifestation of multiple sclerosis. Revista Espanola de Pediatria 45(270): 507-509, 1989

MRI, VEP, SEP and biothesiometry suggest monosymptomatic acute optic neuritis to be a first manifestation of multiple sclerosis. Acta Neurologica Scandinavica 83(5): 343-350, 1991

Optic neuritis. First manifestation of multiple sclerosis? Current diagnostic and therapeutic strategies. Der Ophthalmologe 98(3): 310-318, 2001

Optic neuritis as onset manifestation of multiple sclerosis: a nationwide, long-term survey. Neurology 53(3): 473-478, 1999

The effect of corticosteroids for acute optic neuritis on the subsequent development of multiple sclerosis. The Optic Neuritis Study Group. New England Journal of Medicine 329(24): 1764-1769, 1993

High- and low-risk profiles for the development of multiple sclerosis within 10 years after optic neuritis: experience of the optic neuritis treatment trial. Archives of Ophthalmology 121(7): 944-949, 2003

Multiple sclerosis risk after optic neuritis: final optic neuritis treatment trial follow-up. Archives of Neurology 65(6): 727-732, 2008

A comparative study of visual evoked potentials in optic neuritis and optic neuritis with multiple sclerosis. Journal of the Medical Association of Thailand 90(2): 313-318, 2007

Visual-evoked response differentiation of ischemic optic neuritis from the optic neuritis of multiple sclerosis. American Journal of Ophthalmology 86(4): 530-535, 1978

Multiple Sclerosis Risk After Optic Neuritis: Final Optic Neuritis Treatment Trial Follow-up. Yearbook of Ophthalmology 2009: 187-188, 2009

Association of MMP-2 (⁻1306 C/T) Gene Polymorphism with Predisposition to Optic Neuritis and Optic Neuritis Together with Multiple Sclerosis. Medicina 54(2), 2018

The Relevance of Scanning Laser Polarimetry in the Diagnosis and Follow-Up of Clinically Isolated Acute Optic Neuritis or Optic Neuritis Associated With Chronic Progressive Multiple Sclerosis. ARVO Annual Meeting Abstract Search & Program Planner : Abstract No 2642, 2002