+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Overlap between pathology of Alzheimer disease and vascular dementia



Overlap between pathology of Alzheimer disease and vascular dementia



Alzheimer Disease and Associated Disorders 13 Suppl 3: S115-S123



There is overwhelming evidence to suggest that the neuropathology of Alzheimer disease (AD) extends beyond amyloid plaques and neurofibrillary tangles. Review of various consortium data shows that more than 30% of AD cases exhibit cerebrovascular pathology. However, certain vascular lesions such as cerebral amyloid angiopathy, microvascular degeneration, and periventricular white matter lesions are evident in almost all cases of AD. Whether these vascular lesions are coincidental or causal in the pathogenetic processes of AD remains to be defined. Although systemic vascular influences such as hypertension, coronary artery disease, and other cardiovascular disturbances may be responsible for such pathology in AD, it is equally intriguing that about one third of patients diagnosed with vascular dementia (VaD) will have AD-type pathology at autopsy. Moreover, previous studies have revealed that deficits in cholinergic indices related to the basal forebrain neurones are apparent in multi-infarct dementia. In this short review, we evaluate cerebrovascular pathology of AD in light of peripheral vascular pathophysiology implicated in the etiopathogenesis of the dementia. We also consider pathological findings in relation to genetic influences such as apolipoprotein E that may shed light on the link between AD and VaD. In view of these commonalties, it is reasonable to consider the same treatment strategies for both AD and VaD.

(PDF emailed within 0-6 h: $19.90)

Accession: 046897468

Download citation: RISBibTeXText

PMID: 10609690

DOI: 10.1097/00002093-199912003-00017


Related references

The overlap between Alzheimer's disease and vascular dementia: the role of white matter changes. Dementia and Geriatric Cognitive Disorders 9 Suppl 1: 30-35, 1998

The overlap between vascular disease and Alzheimer's disease--lessons from pathology. Bmc Medicine 12: 206, 2015

Links between the pathology of Alzheimer's disease and vascular dementia. Neurochemical Research 29(6): 1257-1266, 2004

Differential diagnosis and common pathology between Alzheimer's disease and vascular dementia. Rinsho Shinkeigaku 53(11): 915-918, 2015

Oxidative stress in vascular dementia and Alzheimer's disease: a common pathology. Journal of Alzheimer's Disease 17(2): 245-257, 2009

Alzheimer's disease and vascular dementia: one potentially preventable and modifiable disease. Part I: Pathology, diagnosis and screening. Neurodegenerative Disease Management 4(3): 253-259, 2015

Risk of incident clinical diagnosis of Alzheimer's disease-type dementia attributable to pathology-confirmed vascular disease. Alzheimer's and Dementia 13(6): 613-623, 2016

Apo E allele frequencies in Alzheimer's disease, Lewy body dementia, Alzheimer's disease with cerebrovascular disease and vascular dementia. Neuroreport 5(15): 1893-1896, 1994

A longitudinal study of behavioral pathology across five levels of dementia severity in Alzheimer's disease: the CERAD Behavior Rating Scale for Dementia. The Alzheimer's Disease Cooperative Study. Alzheimer Disease and Associated Disorders 11 Suppl 2: S40-S44, 1997

Neuropsychiatric symptoms in dementia-frequency, relationship to dementia severity and comparison in Alzheimer's disease, vascular dementia and frontotemporal dementia. Journal of the Neurological Sciences 236(1-2): 43-48, 2005

Genetic overlap between vascular pathologies and Alzheimer's dementia and potential causal mechanisms. Alzheimer's and Dementia 2018, 2018

Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-beta(42) peptide in vascular dementia. Neuropathology and Applied Neurobiology 32(2): 103-118, 2006

Vascular lesions in mixed dementia, vascular dementia, and Alzheimer disease with cerebrovascular disease: the Kurihara Project. Journal of the Neurological Sciences 322(1-2): 157-160, 2013

Vascular risk factors and Alzheimer's disease: are these risk factors for plaques and tangles or for concomitant vascular pathology that increases the likelihood of dementia? An evidence-based review. Alzheimer's Research and Therapy 4(1): 1, 2011

Impaired imitation of gestures in mild dementia: comparison of dementia with Lewy bodies, Alzheimer's disease and vascular dementia. Journal of Neurology, Neurosurgery, and Psychiatry 86(11): 1248-1252, 2016