+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Overt albuminuria predicts diabetic retinopathy in Hispanics with NIDDM

Overt albuminuria predicts diabetic retinopathy in Hispanics with NIDDM

American Journal of Kidney Diseases 31(6): 947-953

Non-insulin-dependent diabetes mellitus (NIDDM) occurs with a higher frequency in Hispanic as compared with non-Hispanic whites. It also appears that there is a higher prevalence of diabetic nephropathy in the Hispanic population when compared with non-Hispanic whites. In the current study, 144 Hispanics and 671 non-Hispanic white NIDDM subjects were studied to determine the possible association of various risk factors and diabetic complications, including overt albuminuria, with diabetic retinopathy. Stereoscopic retinal fundus photographs were obtained and graded by the University of Wisconsin Fundus Photographic Reading Center. We also sought to determine whether risk factors for retinopathy vary between Hispanics and non-Hispanic whites. In the total group, duration of diabetes, glycosylated hemoglobin, neuropathy, diastolic hypertension, use of insulin, and Hispanic ethnicity correlated with the presence of retinopathy. Controlling for severity and duration of diabetes, Hispanics had a significantly increased risk of retinopathy relative to non-Hispanic whites (OR = 2.13, 95% CI = 1.34, 3.37, P = 0.0013). Duration of diabetes and presence of neuropathy were significantly correlated with the presence of diabetic retinopathy in Hispanics and non-Hispanic whites. The presence of overt albuminuria (>200 microg/min), although not related to diabetic retinopathy in non-Hispanic whites, conferred a high risk for diabetic retinopathy in Hispanics (OR = 11.14, CI = 1.20, 103.39, P = 0.0339) independent of other risk factors. In summary, Hispanics with NIDDM have an increased prevalence of diabetic retinopathy when compared with non-Hispanic whites. In addition, overt albuminuria in the Hispanic subjects appears to be a powerful predictor of the diabetic retinopathy.

(PDF emailed within 0-6 h: $19.90)

Accession: 046897885

Download citation: RISBibTeXText

PMID: 9631838

DOI: 10.1053/ajkd.1998.v31.pm9631838

Related references

The causes of albuminuria in Caucasian NIDDM patients without diabetic retinopathy. Diabetologia 42(SUPPL 1): A268, 1999

Prevalence and risk factors of diabetic retinopathy in non-Hispanic whites and Hispanics with NIDDM. San Luis Valley Diabetes Study. Diabetes 38(10): 1231-1237, 1989

Presence of retinopathy predicts more advanced diabetic nephropathy lesions in Japanese type 2 diabetic patients despite degree of albuminuria. Journal of the American Society of Nephrology 10(PROGRAM AND ABSTR ISSUE): 134A, Sept, 1999

Albuminuria and Diabetic Retinopathy in Type 2 Diabetes Mellitus Sankara Nethralaya Diabetic Retinopathy Epidemiology And Molecular Genetic Study (SN-DREAMS, report 12). Diabetology and Metabolic Syndrome 3(1): 9, 2011

Association of diabetic retinopathy, ischemic heart disease, and albuminuria with diabetic treatment in type 2 diabetic patients. Acta Diabetologica. 34(4): 275-279,., 1997

Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and cardiovascular disease. Diabetes Care 22(1): 125-132, 1999

Control of albuminuria in overt diabetic nephropathy: durability counts. Nephrology, Dialysis, Transplantation 31(9): 1371-1373, 2018

Prevalence and causes of albuminuria in non insulin dependent diabetic niddm patients. Kidney International 37(1): 243, 1990

Incipient and overt diabetic nephropathy in African Americans with NIDDM. Diabetes Care 17(4): 297-304, 1994

Is ACE gene polymorphism a useful marker for diabetic albuminuria in Japanese NIDDM patients?. Diabetes Care 19(12): 1420-1422, 1996

No association between the MTHFR gene polymorphism and diabetic retinopathy in type 2 diabetic patients without overt nephropathy. Diabetes Care 26(6): 1947-8; Author Reply 1948, 2003

Phosphodiesterase Type 5 Inhibition Reduces Albuminuria in Subjects with Overt Diabetic Nephropathy. Journal of the American Society of Nephrology 27(11): 3459-3468, 2016

Effect of suiphated glycosaminoglycans on albuminuria in patients with overt diabetic (type 1) nephropathy. Nephrology Dialysis Transplantation 11(1): 182-185, 1996

Effect of sulphated glycosaminoglycans on albuminuria in patients with overt diabetic (type 1) nephropathy. Nephrology, Dialysis, Transplantation 11(1): 182-185, 1996

White coat hypertension in NIDDM patients with and without incipient and overt diabetic nephropathy. Diabetes Care 20(5): 859-863, 1997