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Patient-controlled analgesia and postoperative nausea and vomiting: efficacy of a continuous infusion of ondansetron



Patient-controlled analgesia and postoperative nausea and vomiting: efficacy of a continuous infusion of ondansetron



Anaesthesia 56(4): 365-369



A continuous infusion of ondansetron was compared with a placebo infusion in 80 patients undergoing major breast reconstructive surgery. All patients received a standard anaesthetic and a bolus dose of ondansetron after induction. They were then randomly allocated to receive an intravenous infusion of ondansetron or a placebo infusion for 24 h in a double-blind fashion. Postoperative analgesia was provided by patient-controlled subcutaneous diamorphine. In the ondansetron group, the severity of nausea, measured by a 10-point verbal rating scale, was reduced (p = 0.01) and fewer patients stated at postoperative interview that nausea and vomiting was a problem (p = 0.01).

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Accession: 046932895

Download citation: RISBibTeXText

PMID: 11284826

DOI: 10.1046/j.1365-2044.2001.01708-5.x


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