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Phat phacts

Phat phacts

Research Initiative Treatment Action 4(7): 11-12

The Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) devoted considerable time to discussing lipodystrophy syndrome, which is characterized by an unusual distribution of fat. Patients began reporting these symptoms approximately 2 years ago, coinciding with the advent of aggressive protease inhibitors. Many concluded that protease inhibitors were somehow related to these symptoms. Because of recent research, that theory may be weakening. Serono Laboratories sponsored a seminar that noted a strong link between lipodystrophy and people with more advanced HIV infection who are faring well on Highly Active Antiretroviral Therapy (HAART). There is still little agreement on the definition of the syndrome and its relationship to serum lipid and glucose abnormalities. There are also concerns that heightened awareness of the problem may be leading to reports of lipodystrophy even when the changes in weight or body shape are minimal.

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Accession: 046973066

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PMID: 11366079

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