+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Phenformin and lactic acidosis: a case report and review

Phenformin and lactic acidosis: a case report and review

Journal of Emergency Medicine 16(6): 881-886

Phenformin was removed from the U.S. market 20 years ago because of a high incidence of lactic acidosis. Unfortunately, this medication is still available from foreign sources. Another biguanide, metformin, was reintroduced to the United States market for the treatment of diabetes. Biguanide-induced lactic acidosis should be included in the differential diagnosis of elevated anion gap metabolic acidosis. We present a case of phenformin-induced lactic acidosis in which we were consulted at the local poison control center. We also review its pathophysiology, presentation, and treatment. A review of the actions of phenformin illustrates the mechanism of pathology that may also occur with metformin. Risk factors for the development of lactic acidosis include renal deficiency, hepatic disease, cardiac disease, and drug interaction such as cimetidine.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 046973146

Download citation: RISBibTeXText

PMID: 9848705

DOI: 10.1016/s0736-4679(98)00103-6

Related references

Phenformin and lactic acidosis. Report of a case and review of the literature. Medical Annals of the District of Columbia 38(10): 548-552, 1969

Insulin therapy in phenformin-associated lactic acidosis; a case report, biochemical considerations and review of the literature. Diabetes 24(1): 28-35, 1975

Phenformin-induced lactic acidosis in an older diabetic patient: a recurrent drama (phenformin and lactic acidosis). Diabetes Care 29(4): 950-951, 2006

Lactic acidosis from phenformin overdose a case report. SMJ Singapore Medical Journal 27(4): 336-340, 1986

Lactic Acidosis and Phenformin Intoxication. Report of two Cases with Review of Literature. California Medicine 103: 198-202, 1965

Phenformin-associated lactic acidosis; a review. American Journal of Hospital Pharmacy 32(5): 502-507, 1975

Phenformin-associated Lactic Acidosis; A Review. American Journal of Health-System Pharmacy 32(5): 502-507, 1975

Lactate kinetics and phenformin clearance in phenformin lactic acidosis treated with hemo dialysis. Clinical Research 25(3): 397A, 1977

Lactic acidosis induced by phenformin with 8 case reports. Acta Clinica Belgica 31(6): 355-363, 1977

Serum phenformin concentrations in patients with phenformin-associated lactic acidosis. Diabetes 26(7): 628-631, 1977

Fatal lactic acidosis from imported phenformin--report of two cases. Singapore Medical Journal 37(5): 482-484, 1996

Phenformin, hypoglycemia and lactic acidosis. Report of attempted suicide. New England Journal of Medicine 275(16): 886-888, 1966

Lactic acidosis and phenformin. A case of successful treatment with hemodialysis. Nordisk Medicin 80(49): 1658-1661, 1968

Phenformin-associated lactic acidosis due to imported phenformin. Diabetes Care 19(12): 1449-1450, 1996

A case of phenformin-induced lactic acidosis complicated by total atrioventricular block. Minerva Cardioangiologica 32(7-8): 489-491, 1984