+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Phenobarbital in Sera of Epileptic Mothers and Their Infants



Phenobarbital in Sera of Epileptic Mothers and Their Infants



American Journal of Therapeutics 2(12): 968-971



The phenobarbital (PB) transition from epiletpic mothers to their breast milks and offspring in cases of PB monopharmacy with other antiepileptic drugs was investigated in 26 epileptic mothers and 24 offspring who were taking the breast milk from epileptic mothers. The mother's serum PB concentration in monopharmacy was almost the same in various stages (stage I, with 5 days after the delivery; stage II, 6--10 days after; stage III, 1--2 mothers after; stage IV, 3--5 months after). However, the PB concentrations in polypharmacy were markedly higher than those in monopharmacy. Concerning the PB concentration in breast milk, a significant increase was found in polypharmacy in comparison with monopharmacy only in stage I. On the other hand, the offspring's PB concentration in polypharmacy was markedly higher than that in monopharmacy, particularly in stage I. In another stages, PB concentration in monopharmacy gradually decreased according to the increase of stages. These results indicate that pharmacokinetics of antiepileptic drugs in the perinatal may be considerably different in PB monopharmacy and polypharmacy.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 046973173

Download citation: RISBibTeXText

PMID: 11854816

DOI: 10.1097/00045391-199512000-00011


Related references

Placental transfer and pharmacokinetics of primidone and its metabolites phenobarbital, PEMA and hydroxyphenobarbital in neonates and infants of epileptic mothers. European Journal of Clinical Pharmacology 18(1): 31-42, 1980

Brain-derived neurotrophic factor in sera of breastfed epileptic infants and in breastmilk of their mothers. Breastfeeding Medicine 10(5): 277-282, 2015

Human IgG subclass study. II. The levels of the individual IgG subclasses in paired sera from mothers and newborn infants as well as in the blood sera of inhabitants of an isolated northern village. Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 1979(7): 35-39, 1979

Detection of HIV-Gag p24-specific antibodies in sera and saliva of HIV-1-infected adults and in sera of infants born to HIV-1-infected mothers. Microbiology and Immunology 42(4): 305-311, 1998

Increasing serum calcium and magnesium concentrations in breast-fed infants: Longitudinal studies of minerals in human milk and in sera of nursing mothers and their infants. Journal of Pediatrics 100(1): 59-64, 1982

Congenital anomalies in infants of epileptic mothers. Neurology 40(4 Suppl. 1): 188, 1990

Hemorrhagic disorders in infants of epileptic mothers. Janz, D Et Al (Ed ) Epilepsy, Pregnancy And The Child; Meeting, Berlin, West Germany, Sept 14-16, 1980 Xx+552p Raven Press: New York, N Y , Usa Illus P387-388, 1982

Neonatal outcome in infants of epileptic mothers. European Journal of Obstetrics Gynecology and Reproductive Biology 16(4): 263-268, 1983

A study on 14 infants born to epileptic mothers. Aggiornamento Pediatrico 41(1): 55-58, 1990

Thyroid function in epileptic mothers and their infants at birth. American Journal of Obstetrics & Gynecology 151(5): 641-644, 1985

Condition of newborn infants born to epileptic mothers. Pediatria Polska 57(5-6): 415-420, 1982

Infants of epileptic mothers developmental scores at 18 months. Wolf, P , Et Al (Ed ) Advances in Epileptology; Xvith Epilepsy International Symposium, Hamburg, West Germany, September 6-9, 1985 Xxviii+787p Raven Press: New York, New York, Usa Illus 579-582, 1987

Screening of infants born to epileptic mothers preliminary results. Epilepsia 26(5): 529, 1985

Factors influencing the risk of malformations among infants of epileptic mothers. Janz, D Et Al (Ed ) Epilepsy, Pregnancy And The Child; Meeting, Berlin, West Germany, Sept 14-16, 1980 Xx+552p Raven Press: New York, N Y , Usa Illus P259-266, 1982

Newborn infants from epileptic mothers: malformation and auxonologic risk. La Pediatria Medica e Chirurgica 11(1): 27-31, 1989