+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Phenobarbital still has a role in epilepsy treatment



Phenobarbital still has a role in epilepsy treatment



Journal of Child Neurology 14(12): 820-821



Phenobarbital, the oldest of the currently available antiepileptic drugs, has lost its popularity in this era of multiple new drugs and is seldom used after infancy in developed countries. We report a group of patients with generalized epilepsy in whom phenobarbital proved to be the drug of choice. Phenobarbital monotherapy was given to 20 patients with idiopathic generalized epilepsy beginning in childhood but persisting into adulthood. All the patients have normal intelligence and neurologic status. The electroencephalogram has either been normal or showed generalized spike-wave discharges. All patients' seizures are fully controlled on once-a-day low-dose phenobarbital with no side effects. Attempts to discontinue the medication have led to recurrence of seizures. We believe that in patients with mild generalized tonic-clonic seizures phenobarbital could still be the drug of choice since it is cheap, safe, convenient, and effective.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 046973187

Download citation: RISBibTeXText

PMID: 10614571

DOI: 10.1177/088307389901401210


Related references

Neurotraumatology and post-traumatic epilepsy. Prevention, treatment and long-term follow-up. Barbexaclone + phenobarbital (maliasin) versus diphenylhydantoin, phenobarbital, primidone, carbamazepine. Minerva Medica 78(22): 1687-1705, 1987

Primary care treatment of epilepsy with phenobarbital in rural China: cost-outcome analysis from the WHO/ILAE/IBE global campaign against epilepsy demonstration project. Epilepsia 49(3): 535-539, 2008

Pregabalin as an adjunct to phenobarbital, potassium bromide, or a combination of phenobarbital and potassium bromide for treatment of dogs with suspected idiopathic epilepsy. Journal of the American Veterinary Medical Association 235(12): 1442-1449, 2009

How phenobarbital revolutionized epilepsy therapy: the story of phenobarbital therapy in epilepsy in the last 100 years. Epilepsia 53(Suppl. 8): 26-39, 2012

Serum triglyceride concentration in dogs with epilepsy treated with phenobarbital or with phenobarbital and bromide. Journal of the American Veterinary Medical Association 233(8): 1270-1277, 2008

Are phenobarbital and phenytoin obsolete in the treatment of epilepsy?. Journal of the Association of Physicians of India 36(7): 458, 1988

Epilepsy after febrile seizures. Predisposing factors and role of phenobarbital in its prophylaxis. Anales Espanoles de Pediatria 15(4): 349-356, 1981

A report on the use of phenobarbital and benzedrine sulphate in the treatment of epilepsy. Dis Nerv System 3(11): 366-370, 1942

Interrelation at plasmatic level between antiepileptic drugs and lipids. Its implications in the efficiency of treatment in epilepsy. II. Influence of some lipid changes upon treatment with phenobarbital or/and diphenylhydantoin. Neurologie et Psychiatrie 19(1): 3, 1981

Phenobarbital treatment and major depressive disorder in children with epilepsy. Pediatrics 80(6): 909-917, 1987

Treatment of grand mal epilepsy: phenobarbital versus diphenylhydantoin sodium. Clinical Pediatrics 7(8): 444-445, 1968

Phenobarbital for the treatment of epilepsy in the 21st century: a critical review. Epilepsia 45(9): 1141-1149, 2004

Concentration of phenobarbital in biological fluids during the treatment of epilepsy patients. Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 84(6): 879-882, 1984

Determination of serum levels of phenobarbital and diphenylhydantoin in the treatment of epilepsy. La Clinica Terapeutica 85(1): 11-18, 1978

Side effects of phenobarbital and phenytoin during long-term treatment of epilepsy. Acta Neurologica Scandinavica. Supplementum 97: 49-67, 1983