+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Phenobarbital, drug metabolism, and human cancer



Phenobarbital, drug metabolism, and human cancer



Cancer Epidemiology Biomarkers and Prevention 2(5): 449-452



To investigate the possible influence of anticonvulsant treatment on cancer risk, a nested case-control study of 104 lung cancers, 18 bladder cancers, and 322 cancer-free controls was conducted. The background for the study was previous observations among 8004 epileptics in Denmark with a significantly high risk for lung cancer and a significantly low risk for bladder cancer. Cigarette smoking appears to explain the lung cancer excess but not the low risk for bladder cancer, another tobacco-related disease. Information was abstracted on 94 and 95% of the cases and controls, respectively. Lung cancer was not associated with any anticonvulsant drug, but bladder cancer was inversely related to use of phenobarbital (PB). The apparent protective effect of PB was further evaluated in a study of rats given 4-aminobiphenyl (ABP), a bladder carcinogen. The levels of 4-aminobiphenyl adducts in hemoglobin and in bladder and liver DNA were significantly lower in rats given PB prior to 4-aminobiphenyl, compared to controls. These studies suggest that PB may induce drug-metabolizing enzymes of the liver that deactivate bladder carcinogens found in cigarette smoke and provide clues to the role of activation and detoxification of carcinogens in humans.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 046973191

Download citation: RISBibTeXText

PMID: 8220089


Related references

Drug metabolism in rats with cancer induced by N-nitrosodiethylamine and phenobarbital. Pharmacology and Toxicology 70(6 Pt 1): 468-474, 1992

Attempts to induce drug metabolism in human fetal liver and placenta by the administration of phenobarbital to mothers. Archives Internationales de Pharmacodynamie et de Therapie 202(2): 288-297, 1973

Induction of drug metabolism-related enzymes by methylcholanthrene and phenobarbital in transgenic mice carrying human prototype c-Ha-ras gene and their wild type littermates. Experimental Animals 50(1): 33-39, 2001

A human drug metabolism database: potential roles in the quantitative predictions of drug metabolism and metabolism-related drug-drug interactions. Current Drug Metabolism 4(5): 411-422, 2003

The effect of phenobarbital on biliary lipid metabolism and hepatic microsomal drug metabolism in patients with cholesterol cholelithiasis. American Journal of Digestive Diseases 21(6): 370-375, 1976

In vitro human hepatocyte-based experimental systems for the evaluation of human drug metabolism, drug-drug interactions, and drug toxicity in drug development. Current Topics in Medicinal Chemistry 14(11): 1325-1338, 2014

Multinuclear NMR study of the metabolism of drug-sensitive and drug-resistant human breast cancer cells. Annals of the new York Academy of Sciences 508: 216-228, 1987

Stimulation of kidney microsomal drug metabolism by phenobarbital. Naunyn-SchmiedebergsArchivfürExperimentellePathologieundPharmakologie259(2):199, 1968

Suppression of hepatic ribonuclease during phenobarbital stimulation of drug metabolism. Biochemical and Biophysical Research Communications 38(4): 811-816, 1970

Studies on the stimulation of drug metabolism by phenobarbital and polycyclic hydrocarbons. Dissertation Abstracts, 27B 4495-4496, 1967

Time course of phenobarbital and cimetidine mediated changes in hepatic drug metabolism. European Journal of Clinical Pharmacology 25(2): 215-222, 1983

Cytochrome P-450 and drug metabolism in Trypanosoma cruzi: effects of phenobarbital. Science 194(4261): 195-197, 1976

Hepatic drug metabolism in ten strains of Norway rat before and after pretreatment with phenobarbital. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 131(1): 256-261, 1969

Drug metabolism in Octodon degus: low inductive effect of phenobarbital. Comparative Biochemistry and Physiology. C Comparative Pharmacology and Toxicology 96(1): 217-222, 1990

Optical Imaging of Drug-Induced Metabolism Changes in Murine and Human Pancreatic Cancer Organoids Reveals Heterogeneous Drug Response. Pancreas 45(6): 863-869, 2016