+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology

Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology

Neurobiology of Aging 22(6): 993-1005

Both oxidative damage and inflammation have been implicated in age-related neurodegenerative diseases including Alzheimer's Disease (AD). The yellow curry spice, curcumin, has both antioxidant and anti-inflammatory activities which confer significant protection against neurotoxic and genotoxic agents. We used 22 month Sprague-Dawley (SD) rats to compare the effects of the conventional NSAID, ibuprofen, and curcumin for their ability to protect against amyloid beta-protein (Abeta)-induced damage. Lipoprotein carrier-mediated, intracerebroventricular infusion of Abeta peptides induced oxidative damage, synaptophysin loss, a microglial response and widespread Abeta deposits. Dietary curcumin (2000 ppm), but not ibuprofen, suppressed oxidative damage (isoprostane levels) and synaptophysin loss. Both ibuprofen and curcumin reduced microgliosis in cortical layers, but curcumin increased microglial labeling within and adjacent to Abeta-ir deposits. In a second group of middle-aged female SD rats, 500 ppm dietary curcumin prevented Abeta-infusion induced spatial memory deficits in the Morris Water Maze and post-synaptic density (PSD)-95 loss and reduced Abeta deposits. Because of its low side-effect profile and long history of safe use, curcumin may find clinical application for AD prevention.

(PDF emailed within 1 workday: $29.90)

Accession: 046973259

Download citation: RISBibTeXText

PMID: 11755008

Related references

Prevention of Abeta amyloid peptide infusion-induced behavioral deficits neuroinflammation and neurodegeneration by dietary anti-inflammatory/antioxidant supplements. Society for Neuroscience Abstracts 26(1-2): Abstract No -680 8, 2000

Dexmedetomidine attenuates isoflurane-induced cognitive impairment through antioxidant, anti-inflammatory and anti-apoptosis in aging rat. International Journal of Clinical and Experimental Medicine 8(10): 17281-8, 2016

Prophylactic melatonin significantly reduces Alzheimer's neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPP(swe)/PS1 mice. Molecular Neurodegeneration 10(): 27-27, 2016

Nobiletin ameliorates isoflurane-induced cognitive impairment via antioxidant, anti-inflammatory and anti-apoptotic effects in aging rats. Molecular Medicine Reports 14(6): 5408-5414, 2016

Glycyrrhizin attenuates isoflurane-induced cognitive deficits in neonatal rats via its anti-inflammatory activity. Neuroscience 316: 328-336, 2016

Attenuation of stress induced memory deficits by nonsteroidal anti-inflammatory drugs (NSAIDs) in rats: Role of antioxidant enzymes. Pharmacological Reports 69(2): 300-305, 2017

Prevention of LTP deficits in Alzheimer transgenic HuAPPSw mice using a phenolic anti-oxidant/anti-inflammatory compound. Society for Neuroscience Abstracts 26(1-2): Abstract No -763 9, 2000

Neuroprotective effect of ginsenoside Rg1 prevents cognitive impairment induced by isoflurane anesthesia in aged rats via antioxidant, anti-inflammatory and anti-apoptotic effects mediated by the PI3K/AKT/GSK-3β pathway. Molecular Medicine Reports 14(3): 2778-2784, 2016

Allicin ameliorates cognitive deficits ageing-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways. Neuroscience Letters 514(1): 46-50, 2012

Curcumin ameliorates cognitive deficits heavy ion irradiation-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways. Pharmacology, Biochemistry, and Behavior 126: 181-186, 2015

Protective effect of stilbenes containing extract-fraction from Cajanus cajan L. on Abeta(25-35)-induced cognitive deficits in mice. Neuroscience Letters 467(2): 159-163, 2010

Dual inhibition of oxidation and inflammation to prevent Abeta-induced Alzheimer pathology and cognitive deficits in a rat model. Society for Neuroscience Abstracts 27(2): 2360, 2001

Antioxidant, anti-glycation and anti-inflammatory activities of phenolic constituents from Cordia sinensis. Molecules 16(12): 10214-10226, 2012

Human anti-Abeta antibodies block Abeta fibril formation and prevent Abeta-induced neurotoxicity. Neurology 60(5 Supplement 1): A69, March 11, 2003

Antioxidant, anti-inflammatory and anti-septic potential of phenolic acids and flavonoid fractions isolated from Lolium multiflorum. Pharmaceutical Biology 55(1): 611-619, 2017