+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Phenolic compounds of Chromolaena odorata protect cultured skin cells from oxidative damage: implication for cutaneous wound healing

Phenolic compounds of Chromolaena odorata protect cultured skin cells from oxidative damage: implication for cutaneous wound healing

Biological and Pharmaceutical Bulletin 24(12): 1373-1379

Extracts from the leaves of Chromolaena odorata have been shown to be beneficial for treatment of wounds. The crude ethanol extract of the plant had been demonstrated to be a powerful antioxidant to protect fibroblasts and keratinocytes in vitro. In this study, the most active compounds were fractionated and identified from the crude extract using liquid chromatography coupled with UV spectroscopy and mass spectrometry. The antioxidant effects of purified fractions on cultured fibroblasts and keratinocytes were investigated using colorimetric and lactate hydrogenase release assay. The results showed that the phenolic acids present (protocatechuic, p-hydroxybenzoic, p-coumaric, ferulic and vanillic acids) and complex mixtures of lipophilic flavonoid aglycones (flavanones, flavonols, flavones and chalcones) were major and powerful antioxidants to protect cultured skin cells against oxidative damage. In conclusion, the extract from C odorata contains a mixture of powerful antioxidant compounds that may be one of potential mechanism contributing to enhanced wound healing.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 046973288

Download citation: RISBibTeXText

PMID: 11767105

Related references

Phenolic Compounds of Chromolaena odorata Protect Cultured Skin Cells from Oxidative Damage: Implication for Cutaneous Wound Healing. Biological & Pharmaceutical Bulletin 24(12): 1373-1379, 2001

Protective effects of curcumin against oxidative damage on skin cells in vitro: its implication for wound healing. Journal of Trauma 51(5): 927-931, 2001

Wound healing activity of Chromolaena odorata leaves. Journal of Tropical Medicinal Plants 8(1): 9-13, 2007

Phenolic compounds protect HepG2 cells from oxidative damage: relevance of glutathione levels. Life Sciences 79(21): 2056-2068, 2006

The wound healing effect of ointment formulation containing Chromolaena odorata on rats. 2007

Hemostatic and Wound Healing Properties of Chromolaena odorata Leaf Extract. Isrn Dermatology 2013: 168269, 2013

Wound Healing Property Review of Siam Weed, Chromolaena odorata. Pharmacognosy Reviews 11(21): 35-38, 2017

Evaluation of in vivo wound healing activity of Chromolaena odorata leaf extract on excision wounds model in rats. Journal of Food Technology 3(2): 126-129, 2005

Phenolic compounds protect cultured hippocampal neurons against ethanol-withdrawal induced oxidative stress. International Journal of Molecular Sciences 10(4): 1773-1787, 2009

Differences between fibroblasts cultured from oral mucosa and normal skin: Implication to wound healing. Journal of Dermatological Science 21(3): 176-182, 1999

Phenolic compounds of Triplaris gardneriana can protect cells against oxidative stress and restore oxidative balance. Biomedicine and PharmacoTherapy 93: 1261-1268, 2017

Ecology and management of Chromolaena odorata: proceedings of the second international workshop on biological control of Chromolaena odorata. Biotrop Special Publication ( 44): 167 pp., 1991

Evaluation of anti-oxidant activities and total phenolic content of Chromolaena odorata. Food and Chemical Toxicology 48(2): 729-732, 2010

Invasive Chromolaena odorata has similar size but higher phenolic concentration than native conspecifics. Evolutionary Ecology Research 15(7): 769-781, 2013

Lignan compounds and 4,4'-dihydroxybiphenyl protect C2C12 cells against damage from oxidative stress. Biochemical and Biophysical Research Communications 344(1): 394-399, 2006