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Phenotype of alveolar lymphocytes--theoretical and practical implications



Phenotype of alveolar lymphocytes--theoretical and practical implications



Przeglad Lekarski 57(9): 493-498



Actual characteristics of alveolar lymphocytes was presented, including author's own experience, i.e. bronchoalveolar lavage (BAL) lymphocyte typing in over 450 patients with interstitial lung diseases (ILD) and bronchial asthma. In healthy individuals as well as in the patients, alveolar lymphocyte population is dominated by T cell subset. Alveolar T lymphocytes present primed memory cell phenotype and usually do not proliferate; in normal conditions apoptosis occurs very seldom. T cytotoxic cell phenotype is characteristic for CD8 subset. Percent of B and NK cells found in BAL is very low--B cells are localized in interstitial space around the pulmonary alveoli, while NK cells do not seem to play the important role in the local pulmonary defense. CD4/CD8 ratio evaluation in BAL material is an auxiliary tool in ILD diagnostics; it reflects local imbalance between T helper primed memory cells and primed T cytotoxic cells.

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Accession: 046973676

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PMID: 11199873


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