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Phenotype of lymphocytes in bronchoalveolar lavage and peripheral blood with different clinical presentations of sarcoidosis



Phenotype of lymphocytes in bronchoalveolar lavage and peripheral blood with different clinical presentations of sarcoidosis



Pneumonologia i Alergologia Polska 64(Suppl. 1): 52-58



The aim of this study was to investigate the relationship between the bronchoalveolar cell counts, the phenotypic characteristics of bronchoalveolar lavage and peripheral lymphocytes and the clinical manifestation of sarcoidosis. 24 patients with sarcoidosis of the lung were examined. Patients were divided into groups based on the presence and the type of clinical symptoms (patients with symptoms of Löfgren syndrome, with constitutional and respiratory symptoms and symptomless patients). The lymphocyte subtypes were analysed using the panel of monoclonal antibodies Simultest IMK Plus with the flow cytometry (Orto Cytoron Absolute). The highest ratio CD4/CD8 in BALF was found in patients with symptoms of Löfgren Syndrome (mean 11.4), the lowest in symptomless patients (mean 4.5). The bronchoalveolar cell count and the percentages of phenotypes of peripheral blood lymphocytes did not differ significantly between the groups of patients. The bronchoalveolar lavage performed in patients with sarcoidosis indicates various intensity of alveolitis dependent on the clinical manifestation.

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Accession: 046973687

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PMID: 9190239


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