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Phenotype of peripheral blood lymphocytes of healthy donors and patients with corneal allotransplantation under conditions of hyperbaric oxygenation



Phenotype of peripheral blood lymphocytes of healthy donors and patients with corneal allotransplantation under conditions of hyperbaric oxygenation



Vestnik Oftalmologii 112(5): 14-16



The purpose of this study was to elucidate the possible immunomodulating effect of hyperbaric oxygenation (HBO) on the immune status of patients with various ophthalmopathies and developing the graft-versus-host reaction after perforating keratoplasty. Surface phenotype of the peripheral blood lymphocytes was studied by two-color flow cytofluorometry in donors and patients with the rejection syndrome after transplantation of the cornea before and after a course of oxygen therapy. HBO exerted no immunodepressive effect, as judged from changes in the subpopulation composition (CD3+, CD4+, CD8+, CD16+, and CD56+) and expression of activation markers (CD25 and HLA-DR), in both patients and donors. The most probable explanation is that HBO effect on the immune system is indirect. On the other hand, from a clinical viewpoint the effect of HBO is undoubtedly positive, and hence, HBO exposure may be recommended for clinical application in transplantations of the cornea.

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Accession: 046973695

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PMID: 9148555


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