+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Phenotypes and genotypes of vancomycin-resistant enterococci isolated during long-term follow-up in a patient with recurrent bacteremia and colonization

Phenotypes and genotypes of vancomycin-resistant enterococci isolated during long-term follow-up in a patient with recurrent bacteremia and colonization

Journal of Microbiology Immunology and Infection 35(4): 243-248

Twenty-seven isolates of vancomycin-resistant enterococci were obtained at monthly intervals from a bed-ridden man with hypoxic encephalopathy. During the 28-month period of the patient's hospitalization, 3 episodes of bacteremia and one episode of catheter-related infection caused by vancomycin-resistant enterococci occurred. Rectal swabs showed colonization of vancomycin-resistant enterococci for more than 2 years. Three months after termination of antimicrobial therapy, the rectal colonization for vancomycin-resistant enterococci was eradicated. Four species (Enterococcus faecium, Enterococcus gallinarum, Enterococcus faecalis, and Enterococcus casseliflavus) were identified among the 27 vancomycin-resistant enterococcus isolates. Three non-clonal related patterns were found among 17 strains of E. faecium by pulsed-field gel electrophoresis. All of the 3 E. faecalis isolates were of the VanB phenotype, but of the vanA genotype. Linezolid had the most potent in vitro activity against these vancomycin-resistant enterococcus isolates, with minimum inhibitory concentrations >2 microg/mL. Eighty-five percent of these vancomycin-resistant enterococcus isolates were susceptible to tetracycline and 66% were susceptible to quinupristin-dalfopristin. Although a high genetic correlation of E. faecium was identified in the patient with prolonged hospitalization, the isolation of 3 genetically unrelated colonized isolates suggested a lack of correlation between infection and colonization. Precautions against resistant organisms, adapted antibiotic policies, and elimination of patient carriage are useful for controlling the spread of vancomycin-resistant enterococci.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 046973740

Download citation: RISBibTeXText

PMID: 12542250

Related references

Recurrent vancomycin-resistant Enterococcus faecium bacteremia in a leukemia patient who was persistently colonized with vancomycin-resistant enterococci for two years. Clinical Infectious Diseases 24(3): 514-515, 1997

Stability of vancomycin-resistant enterococci genotypes isolated from long-term colonized patients. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 36: 220, 1996

Natural history of colonization with vancomycin-resistant enterococci, methicillin-resistant Staphylococcus aureus, and resistant gram-negative bacilli among long-term-care facility residents. Infection Control and Hospital Epidemiology 24(4): 246-250, 2003

Vancomycin-resistant enterococci colonization and bacteremia in patients with hematological malignancies. Journal of Infection in Developing Countries 8(9): 1113-1118, 2014

Skin colonization with vancomycin-resistant enterococci among hospitalized patients with bacteremia. Clinical Infectious Diseases 24(4): 704-706, 1997

Stability of vancomycin-resistant enterococcal genotypes isolated from long-term-colonized patients. Journal of Infectious Diseases 177(2): 378-382, 1998

Patient colonization and environmental contamination by vancomycin-resistant enterococci in a rehabilitation facility. Archives of Physical Medicine and Rehabilitation 83(7): 899-902, 2002

Patient-level analysis of incident vancomycin-resistant enterococci colonization and antibiotic days of therapy. Epidemiology and Infection 144(8): 1748-1755, 2016

Possibility of vancomycin-resistant enterococci transmission from human to broilers, and possibility of using the vancomycin-resistant gram-positive cocci as a model in a screening study of vancomycin-resistant enterococci infection in the broiler chick. Animal Science Journal 77(5): 538-544, 2006

Vancomycin-resistant enterococci in long-term care facilities. Infection Control and Hospital Epidemiology 30(8): 786-789, 2009

Effect of Fidaxomicin versus Vancomycin on Susceptibility to Intestinal Colonization with Vancomycin-Resistant Enterococci and Klebsiella pneumoniae in Mice. Antimicrobial Agents and ChemoTherapy 60(7): 3988-3993, 2016

Evidence for biliary excretion of vancomycin into stool during intravenous therapy: potential implications for rectal colonization with vancomycin-resistant enterococci. Antimicrobial Agents and ChemoTherapy 48(11): 4427-4429, 2004

Lack of increased colonization with vancomycin-resistant enterococci during preferential use of vancomycin for treatment during an outbreak of healthcare-associated Clostridium difficile infection. Infection Control and Hospital Epidemiology 31(7): 710-715, 2010

Survey of long-term-care facilities in Iowa for policies and practices regarding residents with methicillin-resistant Staphylococcus aureus or vancomycin-resistant enterococci. Infection Control and Hospital Epidemiology 26(10): 811-815, 2005

Patients in long-term care facilities: a reservoir for vancomycin-resistant enterococci. Clinical Infectious Diseases 34(4): 441-446, 2002