+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Phenotypes of macrolide, lincosamide, and streptogramin resistant Streptococcus viridans isolated from blood



Phenotypes of macrolide, lincosamide, and streptogramin resistant Streptococcus viridans isolated from blood



Revista Espanola de Quimioterapia 12(4): 346-351



Macrolide resistance has been widely studied in Streptococcus pyogenes and Streptococcus pneumoniae although not in viridans group streptococci (VGS). We studied 30 blood culture isolates of viridans group streptococci (25 resistant to erythromycin: 10 S. mitis, 8 S. milleri, 6 S. sanguis and 1 S. salivarius; and 5 susceptible: 2 S. mitis, 2 S. milleri and 1 S. sanguis). We carried out a double-disk test and determined MICs. The susceptibility testing was carried out by agar dilution for 14-, 15- and 16-member lactone ring macrolides, as well as for clindamycin and quinupristin-dalfopristin. Fifty-six percent of the erithromycin-resistant strains (6 S. mitis, 6 S. milleri and 2 S. sanguis) showed an MLS(B) phenotype, with a high level of intrinsic resistance to all the macrolides studied and clindomycin; 28% were of the M phenotype (4 S. sanguis, 2 S. mitis and 1 S. salivarius). We found a third resistance phenotype, which was present in 4 strains with MICs of 2-8 microg/ml, with resistance to macrolides and different degrees of resistance to clindamycin. All isolates were fully susceptible to quinupristin-dalfopristin. The MLS(B) and M phenotypes initially described in S. pyogenes and S. pneumoniae are also observed in VGS.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 046973760

Download citation: RISBibTeXText

PMID: 10855014


Related references

Erm BC gene and macrolide-lincosamide-streptogramin resistant phenotypes in penicillin-resistant and penicillin-susceptible Streptococcus pneumoniae isolate in Spain. Program & Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 33: 158, 1993

Macrolide-lincosamide-streptogramin B resistant phenotypes and genotypes for methicillin-resistant Staphylococcus aureus in Turkey, from 2003 to 2006. Polish Journal of Microbiology 57(4): 307-312, 2008

Linkage of determinants for streptogramin A, macrolide-lincosamide-streptogramin B, and chloramphenicol resistance on a conjugative plasmid in Enterococcus faecium and dissemination of this cluster among streptogramin-resistant enterococci. International Journal of Medical Microbiology 290(6): 543-548, 2000

Prevalence and characterization of the mechanisms of macrolide, lincosamide and streptogramin resistance in viridans group streptococci. International Journal of Antimicrobial Agents 22(6): 626-629, 2003

Macrolide lincosamide streptogramin b resistance in streptomyces erythreus sequence of the 23s ribosomal rna methylase that mediates resistance and its similarity to other macrolide lincosamide streptogramin resistance methylases. Leive, L (Ed ) Microbiology- ; Meetings Of The American Society For Microbiology X+486p American Society For Microbiology: Washington, D C , Usa Illus 375-378, 1985

Prevalence of resistance phenotypes and genotypes to macrolide, lincosamide and streptogramin antibiotics in Gram-positive cocci isolated in Tunisian Bone Marrow Transplant Center. Pathologie-Biologie 59(4): 199-206, 2011

Heterogeneity of macrolide-lincosamide-streptogramin B resistance phenotypes in enterococci. Antimicrobial Agents and ChemoTherapy 47(11): 3415-3420, 2003

Macrolide, lincosamide, streptogramin resistance in Streptococcus pneumoniae. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 39: 158, 1999

Macrolide-lincosamide-streptogramin B resistance phenotypes in clinical staphylococcal isolates. International Journal of Antimicrobial Agents 31(4): 364-368, 2008

Macrolide-lincosamide-streptogramin B (MLS) resistance in cutaneous propionibacteria: definition of phenotypes. Journal of Antimicrobial ChemoTherapy 23(4): 493-502, 1989

Macrolide resistance in Peptostreptococcus spp. mediated by ermTR: possible source of macrolide-lincosamide-streptogramin B resistance in Streptococcus pyogenes. Antimicrobial Agents and ChemoTherapy 45(2): 630-632, 2001

Streptococcus pneumoniae strains resistance to macrolide, lincosamide, streptogramin, oxazolidinone and ketolide. Mikrobiyoloji Bulteni 36(2): 125-131, 2002

Molecular epidemiology of the macrolide lincosamide streptogramin b resistance phenotypes among staphylococcal isolates from three clinical laboratories. Abstracts of the Annual Meeting of the American Society for Microbiology 86: 2, 1986

Macrolide-lincosamide-streptogramin B resistance phenotypes and genotypes among Staphylococcus aureus clinical isolates in Japan. Clinical Microbiology and Infection 13(3): 325-327, 2007

Environmental macrolide-lincosamide-streptogramin and tetracycline resistant bacteria. Frontiers in Microbiology 2: 40, 2011