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Phenotypic and functional characterization of human prothymocytes



Phenotypic and functional characterization of human prothymocytes



Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales 188(1): 31-38



We report herein the phenotypic and functional analysis of human bone marrow and thymus derived early T cells. Commitment to T cell lineage is acquired during CD7 antigen expression by CD34+ precursors in human bone marrow and before thymus colonization. Early thymocytes show similar phenotypic characteristics as bone marrow T cells. They rapidly acquire CD4 before the dual expression of CD4 and CD8. Their expansion and differentiation is regulated by two major factors: thymic stroma and cytokines produced by these stroma cells or by thymocytes themselves. Among cytokines, IL1 and sCD23 produced by thymic epithelial cells support in vitro early T cell development.

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Accession: 046973841

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PMID: 7994627


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