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Phenotypic and genetic diversity of invasive pneumococcal isolates recovered from French children

Phenotypic and genetic diversity of invasive pneumococcal isolates recovered from French children

Journal of Clinical Microbiology 40(8): 2994-2998

We investigated the phenotypic and genetic diversity (by ribotyping) of Streptococcus pneumoniae isolates recovered from French children, by blood culture from meningitis-free patients (n = 244) and by cerebrospinal fluid culture from patients with meningitis (n = 154). Isolates belonging to serotypes associated with carriage and penicillin-resistant isolates were significantly more frequent in children under 2 years of age than in older children. The seven-valent pneumococcal conjugate vaccine covered 68% of strains associated with bacteremia and 61% of strains associated with meningitis in children under 2 years. Although some serotypes were recovered more frequently from children with bacteremia than from those with meningitis, no difference in the genetic backgrounds of the two groups of strains was found.

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Accession: 046973879

Download citation: RISBibTeXText

PMID: 12149364

DOI: 10.1128/jcm.40.8.2994-2998.2002

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