+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Prevalence and distribution of congenital cardiopathy at birth and in pregnancy termination: impact of prenatal diagnosis in 4 years of experience



Prevalence and distribution of congenital cardiopathy at birth and in pregnancy termination: impact of prenatal diagnosis in 4 years of experience



Acta Bio-Medica de L'ateneo Parmense 71 Suppl 1(): 487-492



To evaluate in two time intervals the potential impact of prenatal diagnosis on prevalence and spectrum of CHD at birth and in aborted fetuses. At the University Hospital of Bari, south-east Italy, in the period between January 1st 1996 and December 31st 1999 a retrospective study was performed of all newborns and termination of pregnancy (TOP) beyond 18 weeks' gestation with postnatally diagnosed CHD. An antenatal fetal ultrasonic evaluation had been always performed between 18-22 weeks' gestation. The prevalence, distribution and detection rate of CHD at birth and in TOP were assessed and compared between two different periods of time (96-97 vs 98-99) to verify an eventual improvement in the prenatal diagnosis due to the learning curve and to new technologies. Prevalence of severe CHD in livebirths and aborted fetuses showed no significant changes between the two study periods (respectively 4.6@1000 vs 5.4@1000, at birth; 10% vs 11%, in TOP) and the same was observed as for as distribution of CHD. Maternal or fetal risk factors were found in 23% of cases of CHD at birth and in 74% of cases of CHD in aborted fetuses. The antenatal detection rate of CHD did not change between the two study periods in newborns (25% vs 27%, NS) while in aborted fetuses it was higher and showed a significant longitudinal improvement (53% vs 85%, p < 0.05), which was more evident if only selected cases were considered (56% vs 93%, p < 0.03). Our data show that gain in experience in fetal echocardiography has increased the prenatal diagnostic accuracy for congenital cardiac malformations only in selected cases, evaluated by more expert operators. In conclusion the impact of antenatal routine screening for congenital heart disease appears still relatively small.

(PDF emailed within 1 workday: $29.90)

Accession: 047059487

Download citation: RISBibTeXText

PMID: 11424794


Related references

The impact of legal termination of pregnancy and of prenatal diagnosis on the birth prevalence of Down syndrome in Denmark. Annals of Human Genetics 47(Pt 2): 123-131, 1983

The impact of prenatal diagnosis on the birth prevalence of malformed children in a region without upper limit for termination of pregnancy. American Journal of Human Genetics 73(5): 591, 2003

Impact of prenatal diagnosis and elective termination on the prevalence of selected birth defects in Hawaii. American Journal of Epidemiology 148(12): 1206-1211, 1998

The impact of prenatal diagnosis and termination of pregnancy on the relative incidence of malformations at birth among Jews and Muslim Arabs in Israel. Israel Medical Association Journal 12(9): 539-542, 2011

Prenatal diagnosis of congenital heart disease and voluntary pregnancy termination Experience of a single tertiary care center. American Journal of Obstetrics & Gynecology 185(6 Suppl.): S254, 2001

Impact of prenatal diagnosis by ultrasound on the prevalence of congenital anomalies at birth in southern France. Journal of Epidemiology and Community Health 48(3): 290-296, 1994

Impact of Prenatal Diagnosis by Ultrasound on the Prevalence of Congenital Anomalies at Birth in Southern France. Journal of Epidemiology and Community Health (1979-) 48(3): 290-296, 1994

Trends in live birth prevalence of congenital anomalies 1979-1999 The impact of prenatal diagnosis. European Journal of Human Genetics 10(Suppl. 1): 275, 2002

Prenatal detection of birth defects in a Malaysian population: estimation of the influence of termination of pregnancy on birth prevalence in a developing country. Australian and New Zealand Journal of Obstetrics and Gynaecology 46(1): 55-57, 2006

EP07.10: Prenatal invasive testing and karyotypic abnormalities in antenatally diagnosed congenital heart defects: impact on timing of diagnosis and termination of pregnancy. Ultrasound in Obstetrics & Gynecology 48 Suppl 1: 294-294, 2016

The diagnosis of congenital and acquired cardiopathy in some of the elementary schools. 3 years of experience. Atti Della Societa Italiana di Cardiologia 2: 51-53, 1968

Termination of pregnancy after prenatal diagnosis of cleft lip and palate--possible influence on reports of prevalence. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 107(6): 759-762, 2009

The impact of prenatal diagnosis and pregnancy termination on overall infant mortality in Canada. Paediatric and Perinatal Epidemiology 15(4): A21-A22, 2001

Influence of prenatal diagnosis and pregnancy termination of fetuses with birth defects on the perinatal mortality rate in Victoria, Australia. Paediatric and Perinatal Epidemiology 19(1): 50-55, 2005

Is the probability of prenatal diagnosis or termination of pregnancy different for fetuses with congenital anomalies conceived following assisted reproductive techniques? A population-based evaluation of fetuses with congenital heart defects. Bjog 122(7): 924-931, 2015