+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Prevalence and outcome of invasive fungal infections in 1,963 thoracic organ transplant recipients: a multicenter retrospective study. Italian Study Group of Fungal Infections in Thoracic Organ Transplant Recipients



Prevalence and outcome of invasive fungal infections in 1,963 thoracic organ transplant recipients: a multicenter retrospective study. Italian Study Group of Fungal Infections in Thoracic Organ Transplant Recipients



Transplantation 70(1): 112-116



Fungal infections (FI) after solid organ transplantation (Tx) remain a major cause of morbidity and mortality. Aspergillus and Candida account for more than 80% of FI. One thousand nine hundred and sixty-three patients undergoing thoracic organ Tx [1,852 heart and 111 lung (35 heart-lung Tx, 30 double-lung Tx, 46 single-lung Tx)] in 12 Italian Centers between November 1985 and January 1997 were included in the study. Fifty-one patients (41 heart Tx - 2.2%; 9 heart-lung Tx - 25.7%; 1 single-lung Tx - 2.2%) developed 53 invasive FI at a median of 58 days (range 6-2479) after Tx. Aspergillosis was the most frequent FI in our series accounting for 64.1% (34/53) of all FI [A fumigatus, n=29 (85.3%); A nidulans, n=2 (5.9%); A niger, n=2 (5.9%); A terreus, n=1 (2.9%)]; 30 (88.2%) patients developed invasive lung aspergillosis, 2 (5.9%) a tracheobronchitis, 1 (2.9%) a skin infection, and 1 (2.9%) a sternal wound infection. Twelve patients (22.6%) developed candidiasis [C albicans, n=8 (66.6%); C krusei, n=1 (8.3%); C glabrata, n=1 (8.3%); C parapsilosis, n=1 (8.3%); C sake, n=1 (8.3%)]. There were seven episodes (58.3%) of candidemia, two (16.7%) esophagitis, two (16.7%) gastritis, and one (8.3%) tracheobronchitis. Mortality was 29.4% for patients developing aspergillosis and 33.3% for those experiencing candidiasis. Furthermore, four patients developed the following: one C neoformans meningitis, one Sporothrix cyanescens pneumonia, one Rhizopus spp. tracheobronchitis, and one Trichosporon beigelii disseminated infection. Three additional patients were diagnosed affected by deep mould infection by histology alone. Deep-seated FI were relatively rare in our series, although their mortality rate is still very high.

(PDF emailed within 1 workday: $29.90)

Accession: 047059736

Download citation: RISBibTeXText

PMID: 10919584


Related references

Prevalence and outcome of invasive fungal infections in 1,963 thoracic organ transplant recipients: A multicenter retrospective study. Transplantation (Baltimore) 70(1): 112-116, July 15, 2000

Prevalence and outcome of invasive fungal infections in 1,956 thoracic organ transplant recipients A multicenter retrospective study. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 37: 322, 1997

Epidemiology and outcome of invasive fungal infections in solid organ transplant recipients. Transplant Infectious Disease 12(3): 220-229, 2010

Italian guidelines for diagnosis, prevention, and treatment of invasive fungal infections in solid organ transplant recipients. Transplantation Proceedings 43(6): 2463-2471, 2012

Invasive Fungal Infections among Organ Transplant Recipients: Results of the Transplant-Associated Infection Surveillance Network (Transnet). Yearbook of Medicine 2010: 96-97, 2010

Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET). Clinical Infectious Diseases 50(8): 1101-1111, 2010

Invasive fungal infections in solid organ transplant recipients. Future Microbiology 7(5): 639-655, 2012

Invasive fungal infections in solid organ transplant recipients. Clinical Microbiology and Infection 20 Suppl 7: 27-48, 2015

Prophylaxis and treatment for invasive fungal infections in solid organ transplant recipients. Nihon Ishinkin Gakkai Zasshi 47(3): 167-169, 2006

Advances in diagnosis and management of invasive fungal infections in organ transplant recipients. Current Opinion in Organ Transplantation 7(4): 320-324, 2002

Invasive fungal infections and antifungal therapies in solid organ transplant recipients. Transplant International 20(12): 993-1015, 2007

Invasive pulmonary fungal infections in solid organ transplant recipients: a four-year review. Transplantation Proceedings 35(7): 2689-2691, 2003

Risk factors, clinical characteristics, and outcomes of invasive fungal infections in solid organ transplant recipients. Transplantation Proceedings 44(9): 2682-2685, 2013

Supplement 1. Focus on Fungal Infections 3 || Clinical Aspects of Fungal Infection in Organ Transplant Recipients. Clinical Infectious Diseases 19: S33-S40, 1994

A multicenter, retrospective study of amphotericin B -induced nephrotoxicity in pediatric bone marrow transplant recipients with invasive fungal infections. Pediatric Research 51(4 Part 2): 252A, 2002