+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prevalence of IgG antibodies against Cytomegalovirus in patients with angiographically demonstrated coronary atherosclerosis



Prevalence of IgG antibodies against Cytomegalovirus in patients with angiographically demonstrated coronary atherosclerosis



Enfermedades Infecciosas Y Microbiologia Clinica 17(8): 386-389



Over the past 25 years the potential role of herpesvirus and particularly Cytomegalovirus as a factor which contribute to atherogenesis, and more recently in restenosis, has been investigated. To determine the rate of Cytomegalovirus seropositivity in patients with angiographically demonstrated Coronary Artery Atherosclerosis. The subjects were all adult patients undergoing coronary angiography at the Hospital Virgen de la Salud, Toledo between February, 1997 and May, 1998. From each patient, blood was drawn and collected to be assayed. Also we collected the data from sex, age, classic risk factors for coronary artery disease (hypertension, hypercholesterolemia, diabetes and cigarette smoking) and catheterization. Data from 437 patients who underwent cardiac catheterization were collected. There was 349 (82.3%) patients who underwent catheterization because of Ischemic Heart Disease. SEROLOGIC ASSAYS: Serum IgG antibodies to cytomegalovirus were measured quantitatively with EIA, VIDAS, (bioMérieux). As recommended by the manufacturer a titer over 6 was considered positive. There was 115 female and 319 males. Patients were 24-86 years old. Data from catheterization showed that 113 patients (26%) have no lesions on coronaryography and 321 patients (74%) have Coronary Artery Disease (CAD). The rate of Cytomegalovirus-seropositive was 97.1% in patients with lesions and 98.2% in those without lesions. There is a high rate of antibodies positive for Cytomegalovirus in the population, in patients with Ischemic Heart Disease and with coronary artery disease as in those without lesions in the coronarigraphy. Our conclusion is that if Cytomegalovirus could have any role in the building of proliferating ateheromas and in view of seroepidemiological studies some other factors must be implicated in the development of plaque growth.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 047060460

Download citation: RISBibTeXText

PMID: 10563085


Related references

Prior infection with cytomegalovirus is not a major risk factor for angiographically demonstrated coronary artery atherosclerosis. Journal of Infectious Diseases 177(1): 209-212, 1998

Cytomegalovirus seropositivity and C-reactive protein have independent and combined predictive value for mortality in patients with angiographically demonstrated coronary artery disease. Circulation 102(16): 1917-1923, 2000

Influence of Cardiovascular Risk Factors on the Prevalence of Coronary Atherosclerosis in Patients with Angiographically Normal Coronary Arteries. Academic Radiology 24(5): 580-586, 2017

Chlamydia pneumoniae antibodies and angiographically demonstrated coronary artery disease in Thailand. Journal of the Medical Association of Thailand 83(9): 1054-1058, 2000

Chlamydia pneumoniae antibodies and angiographically demonstrated coronary artery disease in a sample population from Italy. Atherosclerosis 145(1): 81-85, 1999

Prevalence of angiographically recognizable atherosclerosis in non-dominant right coronary arteries. Angiology 35(12): 760-766, 1984

Pulmonary function in patients with angiographically demonstrated coronary sclerosis. Kardiologiya 20(12): 76-79, 1980

Clinical characteristics of patients with coronary spasm demonstrated angiographically. Revista de Medicina de la Universidad de Navarra 28(3): 56-59, 1984

The association between apolipoprotein polymorphisms and severity of coronary atherosclerosis in Japanese patients with angiographically documented coronary artery disease. Medical Journal of Hiroshima University 44(1): 69-80, 1996

Role of factor V Leiden mutation in patients with angiographically demonstrated coronary artery disease. Thrombosis Research 91(2): 91-99, 1998

Plasma ghrelin levels are closely associated with stenosis severity and morphology of angiographically-detected coronary atherosclerosis in patients with coronary artery disease. International Journal of Cardiology 151(1): 122-123, 2011

Clinical course and results of ischemic heart disease in patients with angiographically demonstrated coronary athero sclerosis. Kardiologiya 16(7): 34-41, 1976

Comparison of parathyroid hormone in angiographically-demonstrated coronary artery disease patients and healthy Thais. Journal of the Medical Association of Thailand 83(Suppl. 2): S106-S110, 2000

Relation between ascending aortic pressures and outcomes in patients with angiographically demonstrated coronary artery disease. American Journal of Cardiology 96(5): 645-648, 2005

Relation between ascending aortic pressures and outcomes in patients with angiographically demonstrated coronary artery disease. American Journal of Cardiology 97(4): 590-591, 2006