+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prevalence of antibiotic resistance of Helicobacter pylori isolates in Estonia during 1995-2000 in comparison to the consumption of antibiotics used in treatment regimens

Prevalence of antibiotic resistance of Helicobacter pylori isolates in Estonia during 1995-2000 in comparison to the consumption of antibiotics used in treatment regimens

Clinical Microbiology and Infection 8(9): 598-603

To find a possible relation between the dynamics of antibiotic resistance of Helicobacter pylori isolates and the consumption of antibiotics during the last several years in Estonia. Helicobacter pylori isolates were collected from the gastric mucosa of patients with peptic ulcer (153) and gastritis (68) and isolated on the Columbia Agar Base. From 1995 to 1997 the disk-diffusion method was used for testing of H. pylori susceptibility to metronidazole (115 isolates), erythromycin (119 isolates), tetracycline (119 isolates) and amoxicillin (119 isolates). From 1998 to 2000 the susceptibility of H. pylori to metronidazole (106 isolates), amoxicillin (30 isolates), clarithromycin (106 isolates) and ciprofloxacin (30 isolates) was assessed by E tests. Data from the Estonian State Agency of Medicines were used to determine the antibiotic consumption rate. Up to the year 2000 all the investigated H. pylori isolates were susceptible to ciprofloxacin; the resistance to clarithromycin, tetracycline, amoxicillin and erythromycin was 3%, 1.7%, 0.7% and 2.5%, respectively. Forty-six percent of H. pylori isolates were resistant to metronidazole. During 1995-2000 the consumption of amoxicillin, erythromycin and ciprofloxacin increased and the consumption of tetracycline decreased. The increasing consumption of amoxicillin reached a level 5.7 times than that of the consistent use of metronidazole. The resistance to amoxicillin appeared to be very low and resistance to metronidazole was continuously high. The increase of clarithromycin consumption (from 0.002 to 1.119 defined daily doses/1000) during three years was associated with the appearance of the first clarithromycin-resistant isolates in 2000. No relation was observed between the antibiotic consumption rate and the resistance pattern of H. pylori to metronidazole, amoxicillin, erythromycin, tetracycline and ciprofloxacin during recent years among the in population.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 047060840

Download citation: RISBibTeXText

PMID: 12427220

DOI: 10.1046/j.1469-0691.2002.00409.x

Related references

Antibiotic susceptibility of Helicobacter pylori in Germany: stable primary resistance from 1995 to 2000. Journal of Medical Microbiology 51(8): 705-709, 2002

Helicobacter pylori resistance to antibiotics in Europe and its relationship to antibiotic consumption. Gut 62(1): 34-42, 2013

High prevalence of primary antibiotic resistance in Helicobacter pylori isolates in Italy. Journal of Gastrointestinal and Liver Diseases 21(4): 363-365, 2012

Influence of resistance of Helicobacter pylori to antibiotics on the Helicobacter pylori eradication regimens. Zhonghua Yi Xue Za Zhi 86(38): 2679-2682, 2006

Prevalence of antimicrobial resistance in Helicobacter pylori isolates in Taiwan in relation to consumption of antimicrobial agents. International Journal of Antimicrobial Agents 34(2): 162-165, 2009

Levofloxacin or Clarithromycin-based quadruple regimens: what is the best alternative as first-line treatment for Helicobacter pylori eradication in a country with high resistance rates for both antibiotics?. Bmc Gastroenterology 17(1): 31, 2017

Antibiotic resistance of Helicobacter pylori: prevalence in one region in the southern Netherlands and implications for treatment. Nederlands Tijdschrift Voor Geneeskunde 158: A7501, 2014

The impact of antibiotic resistance on the efficacy of three 7-day regimens against Helicobacter pylori. Alimentary Pharmacology and Therapeutics 14(7): 893-900, 2000

Antibiotic resistance rates of Helicobacter pylori isolates and the comparison of E-test and fluorescent in situ hybridization methods for the detection of clarithromycin resistant strains. Mikrobiyoloji Bulteni 43(2): 227-234, 2009

Novel and Effective Therapeutic Regimens for Helicobacter pylori in an Era of Increasing Antibiotic Resistance. Frontiers in Cellular and Infection Microbiology 7: 168, 2017

Twice a day quadruple therapy for the first-line treatment of Helicobacter pylori in an area with a high prevalence of background antibiotic resistance. Acta Gastro-Enterologica Belgica 76(1): 34-37, 2013

Appropriate first-line regimens to combat Helicobacter pylori antibiotic resistance: an Asian perspective. Molecules 20(4): 6068-6092, 2015

Resistance of Helicobacter pylori to antibiotics from 2000 to 2009 in Shanghai. World Journal of Gastroenterology 16(40): 5118-5121, 2010

Eradication of Helicobacter pylori with pantoprazole and two antibiotics: A comparison of two short-term regimens. Alimentary Pharmacology and Therapeutics 14(9): 1151-1157, 2000

Antimicrobial resistance among Helicobacter pylori isolates in Alaska, 2000-2016. Journal of Global Antimicrobial Resistance 15: 148-153, 2018