+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prognostic significance of human papillomavirus detected with polymerase chain reaction in cervical cancer



Prognostic significance of human papillomavirus detected with polymerase chain reaction in cervical cancer



Zhonghua Yi Xue Za Zhi 51(2): 97



In order to investigate the prognostic factors of cervical cancer and its association with human papillomavirus (HPV), we analyzed 50 specimens of cervical cancer with a DNA polymerase chain reaction (PCR) mainly to detect HPV types 16 (HPV 16) and 18 (HPV 18). The result showed that at least 74% (37/50) of the specimens had HPV DNA. Among them, 54% (20/37) of the cases were HPV 16 and 32% (12/37) were HPV 18. These HPV DNA positive patients had poorer differentiation in histology than the HPV DNA negative patients. We draw no conclusion about the prognostic significance of HPV DNA in cervical cancer. Perhaps more cases should be analyzed.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 047092274

Download citation: RISBibTeXText

PMID: 8385560

DOI: 10.1016/0020-7292(93)90533-3


Related references

Prognostic significance of polymerase chain reaction detected human papillomavirus of tumors and lymph nodes in surgically treated stage IB cervical cancer. Gynecologic Oncology 47(3): 343-347, 1992

Significance of high-risk human papillomavirus detection by polymerase chain reaction in primary cervical cancer screening. Cytopathology 12(2): 75-83, 2001

Prognostic significance of colorectal cancer micrometastases detected by reverse transcription polymerase chain reaction. Gut 42(Suppl. 1): A90, 1998

Detection of human papillomavirus DNA in invasive cervical cancers by the polymerase chain reaction and its clinical significance. Acta Pathologica Japonica 42(12): 876-883, 1992

Human papillomavirus type 16 DNA detected by the polymerase chain reaction in non-cancer tissues of the head and neck. European Archives Of Oto-Rhino-Laryngology. 251(2): 109-112, 1994

Detection of human papillomavirus in cervical scrapes by the polymerase chain reaction in relation to cytology: possible implications for cervical cancer screening. Iarc Scientific Publications 1992(119): 271-281, 1992

Detection of human papillomavirus DNA in cervical cancer tissue by the polymerase chain reaction. Journal of Virological Methods 26(1): 17-25, 1989

Human papillomavirus (HPV) in high-grade cervical intraepithelial neoplasia (CIN) detected by morphology and polymerase chain reaction (PCR)-- a cytohistologic correlation of 277 cases treated by laser conization. Cytopathology 10(2): 112-121, 1999

Prognostic significance of peritoneal minimal residual disease in gastric cancer detected by reverse transcription-polymerase chain reaction. British Journal of Surgery 91(4): 435-443, 2004

Use of the polymerase chain reaction to study the relationship between human papillomavirus infections and cervical cancer. European Journal of Clinical Microbiology & Infectious Diseases 10(9): 714-727, 1991

Prognostic significance of gastric cancer metastasis in second-tier lymph nodes detected on reverse transcriptase-polymerase chain reaction and immunohistochemistry. Pathology International 58(1): 45-50, 2008

Prognostic significance of occult bone marrow micrometastases of breast cancer detected by quantitative polymerase chain reaction for cytokeratin 19 mRNA. Japanese Journal of Cancer Research 91(9): 918-924, 2000

A Polymerase Chain Reaction-Enzyme-Linked Immunosorbent Assay Method for Detecting Human Papillomavirus in Cervical Carcinomas and High-Grade Cervical Cancer Precursors. Obstetrics & Gynecology. 85(3): 337-342, 1995

Human papillomavirus detection for cervical cancer prevention with polymerase chain reaction in self-collected samples. American Journal of Obstetrics & Gynecology 186(5): 962-968, 2002

Human papillomavirus detection using polymerase chain reaction in cervical cancer tissue and paraaortic lymph nodes. Journal of Catholic Medical College 46(4): 1655-1665, 1993