+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prognostic significance of proliferative activity and ploidy in node-negative breast cancers



Prognostic significance of proliferative activity and ploidy in node-negative breast cancers



Annals of Oncology 4(3): 213-219



Cell kinetics and DNA ploidy have provided relevant information on the natural history of breast cancer. We assessed the prognostic role of proliferative activity and ploidy, alone and in association with tumor size, estrogen (ER) and progesterone (PgR) receptors. In a series of 340 women with resectable node-negative breast cancers given local-regional therapy alone until relapse, proliferative activity was determined as the 3H-thymidine labeling index (3H-dT LI) and flow-cytometric S-phase cell fraction (FCM-S), as quantified by using different modeling systems. DNA ploidy, ER and PgR content were determined on frozen samples by FCM and by the dextran-coated charcoal absorption technique, respectively. FCM-S estimates obtained by the different models were weakly associated with one another and to the corresponding 3H-dT LIs. Four-year relapse-free survival was significantly predicted by 3H-dT LI, ploidy and tumor size but not by FCM-S. Multiple regression analysis showed that 3H-dT LI, ploidy and tumor size retained their prognostic significance and that 3H-dT LI was the most significant indicator of relapse (p = 0.009). The finding that 3H-dT LI and ploidy are weakly related and provide independent prognostic information could allow a more accurate identification of patients at different risk of relapse.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 047092443

Download citation: RISBibTeXText

PMID: 8471553

DOI: 10.1093/oxfordjournals.annonc.a058458


Related references

Lack of prognostic significance of the monoclonal antibody Ki-S1, a novel marker of proliferative activity, in node-negative breast carcinoma. Breast Cancer Research & Treatment. 37(2): 123-133, 1996

Prognostic significance of P53 in node negative T1/T2-breast cancers. Breast Cancer Research & Treatment 57(1): 101, 1999

The prognostic significance of the S-phase fraction and DNCA ploidy in node-negative estrogen receptor-positive breast cancer. Philippine Journal of Surgical Specialties 53(1): 25-30, 2002

Tumour proliferative activity is predictive of 10-year relapse in patients with node-negative, low-risk breast cancers. Breast 12(Suppl. 1): S23, 2003

Prognostic relevance of receptor status and proliferative activity in node negative breast cancer. Journal of Cellular Biochemistry Suppl. (11 PART A): 129, 1987

The prognostic value of p53 and c-erbB-2 expression, proliferative activity and angiogenesis in node-negative breast carcinoma. Tumori 91(1): 46-52, 2005

Prognostic relevance of proliferative activity evaluated by Mib-1 immunostaining in node negative breast cancer. European Journal of Surgical Oncology 34(12): 1299-1303, 2008

The prognostic value of oncogenic antigen 519 (OA-519) expression and proliferative activity detected by antibody MIB-1 in node-negative breast cancer. Journal of Pathology 176(4): 343-352, 1995

Prognostic significance of DNA ploidy and proliferative index in breast carcinoma. Archives of Surgery 123(6): 783, 1988

Multivariate prognostic evaluation of the mitotic activity index and fibrotic focus in node-negative invasive breast cancers. European Journal of Cancer 41(14): 2093-2101, 2005

Dna ploidy as a prognostic indicator in node negative breast cancer. Analytical Cellular Pathology 4(3): 215, 1992

Prognostic value of DNA ploidy in 653 Japanese women with node-negative breast cancer. International Journal of Clinical Oncology 6(4): 177-182, 2001

Ki-67, p53, Er-receptors, ploidy and S-phase as prognostic factors in T1 node negative breast cancer. Acta Oncologica 36(4): 369-374, 1997

Is DNA ploidy an independent prognostic indicator in infiltrative node-negative breast adenocarcinoma?. Cancer 65(7): 1577-1582, 1990

Node negative breast cancer: the prognostic value of DNA ploidy for long-term survival. British Journal of Surgery 78(7): 844-848, 1991