+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Prophylaxis of heterotopic ossification after total hip arthroplasty: a prospective randomized study comparing indomethacin and meloxicam



Prophylaxis of heterotopic ossification after total hip arthroplasty: a prospective randomized study comparing indomethacin and meloxicam



Acta Orthopaedica Scandinavica 73(6): 611-614



We performed a randomized, prospective study on the prophylaxis of heterotopic ossification (HO) after total hip arthroplasty (THR), comparing indomethacin and the selective COX-2 inhibitor meloxicam. From the day after surgery, 272 patients were treated with 7.5 mg meloxicam, 15 mg meloxicam, or 2 x 50 mg indomethacin a day, for 14 days. After 6 months, radiographs of patients treated with 7.5 mg meloxicam showed that HO had occurred in one third. This treatment was therefore stopped after 26 patients have been assigned to this group. According to the intention-to-treat principle, patients given 15 mg meloxicam developed HO in 25% (20% Brooker grade I, 4% grade II and 1% grade III) and those given indomethacin in 10% (7% Brooker grade I, 1% grade II and 2% grade III), a statistically significant difference.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 047103268

Download citation: RISBibTeXText

PMID: 12553505


Related references

Prophylaxis for heterotopic ossification after primary total hip arthroplasty. A cohort study between indomethacin and meloxicam. Acta Orthopaedica Belgica 70(3): 240-246, 2004

Indomethacin versus meloxicam for prevention of heterotopic ossification after total hip arthroplasty. Archives of Orthopaedic and Trauma Surgery 123(2-3): 91-94, 2003

Incidence of heterotopic ossification after surface and conventional total hip arthroplasty: a comparative study using anterolateral approach and indomethacin prophylaxis. Biomed Research International 2013: 293528, 2013

Indomethacin for 3 days is not effective as prophylaxis for heterotopic ossification after primary total hip arthroplasty. Journal of Arthroplasty 14(7): 796-799, 1999

General short-term indomethacin prophylaxis to prevent heterotopic ossification in total hip arthroplasty. Orthopedics 22(2): 207-211, 1999

Heterotopic Ossification Prophylaxis After Total Hip Arthroplasty: Randomized Trial of 400 vs 700 cGy. Journal of Arthroplasty 32(4): 1328-1334, 2017

The efficacy of 500 CentiGray radiation in the prevention of heterotopic ossification after total hip arthroplasty: a prospective, randomized, pilot study. Journal of Arthroplasty 18(6): 677-686, 2003

Prevention of heterotopic bone formation after total hip arthroplasty: A prospective randomised study comparing postoperative radiation therapy with indomethacin medication. Archives of Orthopaedic & Trauma Surgery 119(5-6): 296-302, 1999

Preventive effects of ibuprofen on periarticular heterotopic ossification after total hip arthroplasty: A randomized double-blind prospective study of treatment time. Acta Orthopaedica Scandinavica 69(2): 111-115, 1998

Preliminary results of a randomized trial comparing 400 cGy vs 700 cGy as an adjuvant to prevent heterotopic ossification after total hip arthroplasty. International Journal of Radiation Oncology Biology Physics 39(2 Suppl. ): 154, 1997

Heterotopic ossification after surface replacement arthroplasty and total hip arthroplasty: a randomized study. Journal of Arthroplasty 24(2): 256-262, 2009

Adherence to routine use of pharmacological prophylaxis of heterotopic ossification after total hip arthroplasty: results from an Italian multicenter, prospective, observational survey. Journal of Orthopaedics and Traumatology 13(2): 63-67, 2012

Indomethacin versus radiation therapy for prophylaxis against heterotopic ossification in acetabular fractures: a randomised, prospective study. Journal of Bone and Joint Surgery. British Volume 80(2): 259-263, 1998