+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Regulation of gene expression by human foamy virus and potentials of foamy viral vectors

Regulation of gene expression by human foamy virus and potentials of foamy viral vectors

Stem Cells 15(Suppl 1): 141-147

ISSN/ISBN: 1066-5099

PMID: 9368334

DOI: 10.1002/stem.5530150818

The hallmarks of the spumaretrovirus or human foamy virus (HFV) are summarized and discussed with special focus on the potentials to use HFV as a new retroviral vector system. The special features of HFV are the expression of pol by splicing and start of translation at a defined initiation codon. The first Met of Pol is conserved in the six known foamy virus genomic sequences. Another remarkable characteristic of HFV is the presence of a Gly-Arg-rich sequence instead of the Cys-Cys motif of the classical retroviral nuclecapsid proteins. The preferential budding of HFV into cytoplasmic vesicles and the potential to exploit it in the application of corresponding vector systems is discussed. In addition, recent reports of transducing marker genes into susceptible cells will be reviewed.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 047213274

Download citation: RISBibTeXText

Related references

Isolement d'un nouveau rétrovirus foamy chez le cheval : l'EFV (equine foamy virus) - Isolation of a new foamy virus : the equine foamy virus. Virologie (Montrouge) 4(3): 248-249, 2000

Transduction of human neural progenitor cells with foamy virus vectors for differentiation-dependent gene expression. Gene Therapy 16(3): 349-358, 2009

Efficient therapeutic gene expression in cultured rat hippocampal neurons mediated by human foamy virus vectors: a potential for the treatment of neurological diseases. Intervirology 48(5): 329-335, 2005

Recombinant foamy virus vectors for medicinal, and diagnostic uses, and processes for preparing recombinant foamy virus vectors. Official Gazette of the United States Patent and Trademark Office Patents 1200(2): 1255, 1997

Gene transfer using replication-defective human foamy virus vectors. Virology 235(1): 65-72, 1997

Regulation of foamy virus gene expression. Current Topics in Microbiology and Immunology 193: 1-24, 1995

Human foamy virus Bel 1 transactivator/estrogen receptor fusion proteins allow inducible transactivation of both human foamy virus promoters. Virus Genes 21(3): 209-213, 2000

Human foamy virus: further characterization, seroepidemiology, and relationship to chimpanzee foamy viruses. Journal of Infectious Diseases 137(4): 421-427, 1978

Antigenic relationship of human foamy virus to the simian foamy viruses. Infection and Immunity 20(1): 69-72, 1978

Infectious proviral clones of chimpanzee foamy virus (SFVcpz) generated by long PCR reveal close functional relatedness to human foamy virus. Virology 214(2): 685-689, 1995

Improved foamy virus vectors with minimal viral sequences. Molecular Therapy: the Journal of the American Society of Gene Therapy 6(3): 321-328, 2002

Isolation, cloning, and sequencing of simian foamy viruses from chimpanzees (SFVcpz): high homology to human foamy virus (HFV). Virology 201(2): 187-199, 1994

Isolation, cloning, and sequencing of simian foamy viruses from chimpanzees (SFVcpz) : high mology to human foamy virus (HFV). Virology (New York) 201(2): 187-199, 1994

Regulation of gene expression of simian foamy virus type 1 and 3. Journal of Cellular Biochemistry Suppl (16 Part E): 38, 1992

Ex vivo gene delivery to synovium using foamy viral vectors. Journal of Gene Medicine 16(7-8): 166-178, 2014