+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Risk factors for recurrent bleeding and mortality in human immunodeficiency virus infected patients with acute lower GI hemorrhage



Risk factors for recurrent bleeding and mortality in human immunodeficiency virus infected patients with acute lower GI hemorrhage



Gastrointestinal Endoscopy 49(6): 748-753



Little is known about lower gastrointestinal (GI) hemorrhage in the human immunodeficiency virus (HIV) infected population. Our aim was to determine the underlying causes, the clinical outcome, and the risk factors for recurrent bleeding and mortality in HIV-infected patients with acute LGIH. We reviewed the medical records of consecutive HIV-infected patients with acute lower GI hemorrhage who were evaluated with endoscopy from January 1992 through January 1997 at Bellevue Hospital Center. During the 5-year study period, 312 patients with acute lower GI hemorrhage underwent colonoscopy (n = 233) or flexible sigmoidoscopy (n = 79). Cytomegalovirus colitis (25.3%), lymphoma (12.2%), and idiopathic colitis (12.2%) were the most common causes identified. Within 30 days of presentation, recurrent bleeding occurred in 17.6% of patients. Independent predictors of recurrent bleeding included the presence of at least one comorbid illness, a hemoglobin level of less than 8 gm/dL, a platelet count of less than 100,000/mm3, and major stigmata of hemorrhage. The 30-day mortality from lower GI hemorrhage was 14.4%, and the presence of comorbid disease, recurrence of bleeding, and surgical intervention were found to be the only independent predictors of mortality in this patient population. Acute lower GI hemorrhage in HIV-infected patients is most commonly caused by cytomegalovirus colitis and is associated with a high short-term morbidity and mortality.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 047276176

Download citation: RISBibTeXText

PMID: 10343221


Related references

Risk factors for rebleeding and mortality from acute upper gastrointestinal hemorrhage in human immunodeficiency virus infection. American Journal of Gastroenterology 94(2): 358-363, 1999

Bloodstream infections among human immunodeficiency virus-infected adult patients: epidemiology and risk factors for mortality. European Journal of Clinical Microbiology and Infectious Diseases 27(10): 969-976, 2008

Nosocomial bloodstream infection in human immunodeficiency virus-infected patients in Taiwan: descriptive epidemiology and risk factors for mortality. Journal of the Formosan Medical Association 103(10): 743-748, 2004

Recurrent lower gastrointestinal bleeding secondary to cytomegalovirus-associated colonic ulcer in a non human immunodeficiency virus infected patient: timely diagnosis and treatment averted surgery. Colorectal Disease 11(9): 984-985, 2010

Angiographic features and cardiovascular risk factors in human immunodeficiency virus-infected patients with first-time acute coronary syndrome. American Journal of Cardiology 111(1): 63-67, 2013

Risk factors of persistent or recurrent bleeding and mortality in peptic ulcer hemorrhage. Helvetica Chirurgica Acta 60(4): 661-664, 1994

Trichomoniasis in pregnant human immunodeficiency virus-infected and human immunodeficiency virus-uninfected congolese women: prevalence, risk factors, and association with low birth weight. American Journal of Obstetrics and Gynecology 181(3): 656-662, 1999

Risk factors for pneumococcal disease in human immunodeficiency virus-infected patients. Journal of Infectious Diseases 173(4): 857-862, 1996

Risk factors for intestinal microsporidiosis in patients infected with human immunodeficiency virus. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 37: 271, 1997

Prevalence, risk factors and genetic characterization of human T-cell lymphotropic virus types 1 and 2 in patients infected with human immunodeficiency virus type 1 in the cities of Ribeirão Preto and São Paulo. Revista Da Sociedade Brasileira de Medicina Tropical 42(3): 264-270, 2009

Risk factors, seasonality, and trends of cryptosporidiosis among patients infected with human immunodeficiency virus. American Journal of Tropical Medicine and Hygiene 62(3): 384-387, 2000

Risk factors for fluconazole-resistant candidiasis in human immunodeficiency virus-infected patients. Journal of Infectious Diseases 173(1): 219-225, 1996

About "Factors determining irregular attendance to follow-up visits among human immunodeficiency virus patients: Results of a hospital survey of patients infected with human immunodeficiency virus, 2002-2012". Enfermedades Infecciosas Y Microbiologia Clinica 34(4): 270-272, 2016

Factors determining irregular attendance to follow-up visits among human immunodeficiency virus patients: results of the hospital survey of patients infected with human immunodeficiency virus. Enfermedades Infecciosas Y Microbiologia Clinica 33(5): 324-330, 2017

Incidence and risk factors for tenofovir-associated nephrotoxicity among human immunodeficiency virus-infected patients in Korea. Korean Journal of Internal Medicine 2017, 2017