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Role of nitric oxide in asthma-like symptoms induced by diesel exhaust particles in mice


, : Role of nitric oxide in asthma-like symptoms induced by diesel exhaust particles in mice. Nihon Kyobu Shikkan Gakkai Zasshi 33 Suppl: 212-217

Asthma-like symptoms were induced in mice by repeated intratracheal instillation of diesel exhaust particles. Nitric oxide synthase (NOS) and superoxide dismutase (SOD) in airways were studied with immunocytochemical methods, and the role of nitric oxide was examined with the NOS inhibitor L-NMMA. Diesel exhaust particles increased the staining of cNOS in airway epithelial cells by an anti-cNOS antibody. Macrophages in the mucous membrane were stained clearly, but an anti-iNOS antibody did not stain airway epithelial cells. Diesel exhaust particles caused a 4-fold increase in the total number of macrophages, neutrophils, eosinophils, and lymphocytes in bronchoalveolar lavage fluid. Diesel exhaust particles decreased the staining of Cu, Zn-SOD, and Mn-SOD in epithelial cells by their respective anti-SOD antibodies. Diesel exhaust particles doubled the concentration of nitric oxide in exhaled air. These particles increased respiratory resistance, and this increase was suppressed by pretreatment with the NOS inhibitor L-NMMA. These results suggest that diesel exhaust particles can decrease the scavenging of O2- in airways, which may increase hyperresponsiveness. In mice exposed to diesel exhaust particles, the increase in NOS staining in airway epithelium, the increase in the nitric oxide concentration in exhaled air, and the decrease in respiratory resistance caused by L-NMMA indicate that nitric oxide may increase airway hyperresponsiveness.

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Accession: 047287059

PMID: 8752509

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Anonymous, 1985: Report - 1985. Items abstracted appear in the appropriate sections of ABA.

Gutiérrez Fuentes, J.A.; Martín Santos, J.; López Alonso, G.; Mateos Sánchez, A., 1976: Encapsulating peritonitis and peritoneal hydatidosis. Revista Clinica Espanola 141(5): 487-490

Yahia N.; Seibel W.; Mccleary L.; Lesko L.; Hassell T., 1988: Effect of toothbrushing on cyclosporine induced gingival overgrowth in beagles. Journal of Dental Research 67(SPEC ISSUE MAR): 332

Rosthøj, S.; Keiding, N.; Schmiegelow, K., 2012: Estimation of dynamic treatment strategies for maintenance therapy of children with acute lymphoblastic leukaemia: an application of history-adjusted marginal structural models. Childhood acute lymphoblastic leukaemia is treated with long-term intensive chemotherapy. During the latter part of the treatment, the maintenance therapy, the patients receive oral doses of two cytostatics. The doses are tailored to blood counts...

Baumann; Bounajma; Huck; Klotz; Knipper; Walter; Marguier; Richard-Serre; Ravn; Hagebo; Hoff; Steffensen, 1994: Beta decay properties of 67,68Se and the astrophysical rp-process path. Physical Review. C, Nuclear Physics 50(2): 1180-1184

Wasserstrom, V. M.; Schwab, C. G.; Whitehouse, N. L.; Kierstead, N. A.; Socha, M. T.; Putnam, D. E.; Garthwaite, B. D., 1995: Dry matter intake, passage of nitrogen fractions and amino acids to the small intestine and blood metabolites during the periparturient period of Holstein cows. Journal of Dairy Science 78(SUPPL 1): 215

Sutherland, R. F., 2002: New energy options in the Australian sugar industry. Since the introduction of the 2% renewables requirement in the electricity industry, there have been significant incentives for Australian sugar mills to improve their energy performance. With the addition of an attached distillery producing ethan...

Mikaelyan A.L.; Mkrtchyan A.A.; Gusakova N.F.; Ayunts M.B., 1983: Results of constructive operations in thrombo obliterating diseases of vessels of the lower extremities depending on the degree of changes in blood supply and tissue metabolism. The effect of disturbed blood supply and energy muscle metabolism on the results of reconstructive operations on the arteries of the lower extremities was studied in 120 patients with obliterating endarteritis and atherosclerosis. Despite the reco...

Tamaki, K.; Yoshimura, J.; Okuda, S., 2006: Molecular biology in regulation of kidney function: TGF-beta (transforming growth factor-beta). Nihon Rinsho. Japanese Journal of Clinical Medicine 64 Suppl 2: 297-301

STEIN, S.; PAXSON, N.F., 1963: Use of a monoamine oxidase inhibitor in obstetrics. American Journal of Obstetrics and Gynecology 85: 507-510