SR 48692, a non-peptide neurotensin receptor antagonist, blocks the cardiovascular effects elicited by neurotensin in guinea pigs

Nisato, D.; Guiraudou, P.; Barthélémy, G.; Gully, D.; Le Fur, G.

Life Sciences 54(7): Pl95

1994


ISSN/ISBN: 0024-3205
PMID: 8309346
DOI: 10.1016/0024-3205(94)00411-0
Accession: 047299203

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Abstract
In guinea pigs anaesthetized with sodium pentobarbital, SR 48692, a non peptide neurotensin receptor antagonist blunted the blood pressure increase induced by exogenous neurotensin in a dose dependent manner. Furthermore, in isolated spontaneously beating guinea pig atria, both the tachycardia and inotropic responses induced by neurotensin were potently antagonized. SR 48692 did not show any intrinsic effect in vivo or in vitro.