+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

STAT5 signaling in sexually dimorphic gene expression and growth patterns

STAT5 signaling in sexually dimorphic gene expression and growth patterns

American Journal of Human Genetics 65(4): 959-965

The past 10 years have seen enormous advances in our understanding of how cytokine signals are mediated intracellularly. Of particular significance was the discovery of a family of seven Signal Transducer and Activators of Transcription (STAT) proteins. Each of these has now been studied in detail, and appropriate gene-disrupted mouse models are available for all except STAT2 (Leonard and O'Shea 1998). Fetal lethality is observed in Stat3-deficient mice, and various immunodeficiencies characterize mice with disrupted Stat1, Stat4, and Stat6 genes, which is consistent with impaired signaling from the specific cytokines that activate each of these proteins. The recent characterization of Stat5-deficient mice has led to several unanticipated findings that point to diverse biological functions for the two STAT5 forms, STAT5a and STAT5b. These include roles for one or both STAT5 forms in the immune system, hematopoiesis, sexually dimorphic growth, mammary development, hair growth, deposition of adipose tissue, and pregnancy. Here we review the hormone- and cytokine-activated signaling pathways in which STAT5 participates and the extensive evidence, from laboratory animals, that these factors are required for sex-specific aspects of development, including control of body size. Finally, we consider human growth disorders that may involve defects in STAT5-dependent signal transduction.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 047299551

Download citation: RISBibTeXText

PMID: 10486314

DOI: 10.1086/302599

Related references

A new in vivo analysis model to detect sexually dimorphic rat liver cytochrome P450 gene expression dependent on growth hormone secretory patterns. Experimental Animals 65(4): 447-454, 2016

PDF-1 neuropeptide signaling regulates sexually dimorphic gene expression in shared sensory neurons of C. elegans. Elife 7:, 2018

Developmental and sexually dimorphic patterns of somatostatin gene expression in the periventricular nucleus of the rat brain. Journal of Cellular Biochemistry Suppl. (14 Part F): 39, 1990

Sexually dimorphic gene expression patterns during gonadal differentiation in olive flounder, Paralichthys olivaceus. Animal Biology 65(3-4): 193-207, 2015

Spatial, temporal, and sexually dimorphic expression patterns of the fruitless gene in the Drosophila central nervous system. Journal of Neurobiology 43(4): 404-426, 2000

Interpulse interval in circulating growth hormone patterns regulates sexually dimorphic expression of hepatic cytochrome P450. Proceedings of the National Academy of Sciences of the United States of America 88(15): 6868-6872, 1991

Growth hormone (GH) secretion, GH-dependent gene expression, and sexually dimorphic body growth in young rats with chronic renal failure. Endocrine 33(3): 323-330, 2008

Growth hormone pretranslationally regulates the sexually dimorphic expression of the prolactin receptor gene in rat liver. Molecular Endocrinology 4(8): 1235-1239, 1990

Sexually Dimorphic Gene Expression Associated with Growth and Reproduction of Tongue Sole (Cynoglossus semilaevis) Revealed by Brain Transcriptome Analysis. International Journal of Molecular Sciences 17(9):, 2016

Gapes of sexually dimorphic blackbird nestlings do not show sexually dimorphic growth. Auk 112(2): 364-374, 1995

Differential gene expression patterns in developing sexually dimorphic rat brain regions exposed to antiandrogenic, estrogenic, or complex endocrine disruptor mixtures: glutamatergic synapses as target. Endocrinology 156(4): 1477-1493, 2015

Sexually dimorphic expression of the growth hormone-releasing hormone gene is not mediated by circulating gonadal hormones in the adult rat. Endocrinology 128(4): 1709-1716, 1991

A STAT factor mediates the sexually dimorphic regulation of hepatic cytochrome P450 3A10/lithocholic acid 6 beta-hydroxylase gene expression by growth hormone. Molecular and Cellular Biology 15(9): 4672-4682, 1995

Temporal relationship between the sexually dimorphic spontaneous GH secretory profiles and hepatic STAT5 activity. Endocrinology 142(11): 4599-4606, 2001

Plasma growth hormone pulse activation of hepatic JAK-STAT5 signaling: developmental regulation and role in male-specific liver gene expression. Endocrinology 141(9): 3245-3255, 2000