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Secretory IgA epitopes in basal tears of extended-wear soft contact lens wearers and in non-lens wearers

Secretory IgA epitopes in basal tears of extended-wear soft contact lens wearers and in non-lens wearers

Australian and New Zealand Journal of Ophthalmology 27(3-4): 221-223

To determine secretory IgA epitopes in tears of extended-wear soft contact lens wearers and non-wearing controls. We developed enzyme-linked immunosorbent assays (ELISA) to determine the tear concentrations of two epitopes of secretory IgA, the IgA alpha-chain and the secretory component. These epitopes were measured in basal tears of 20 individuals in 6 nights of extended wear of etafilcon A soft contact lenses and in 19 non-lens-wearing individuals. Levels of IgA alpha-chain immunoreactivity were significantly decreased in the lens-wearing group compared to non-lens wearers. However, the level of secretory component immunoreactivity was not significantly different between groups. IgA alpha-chain and secretory component immunoreactvity were highly correlated; however, some samples showed a marked variation between these two values. Tear concentrations of sIgA epitopes are significantly reduced in extended-wear contact lens wearers, and may contribute to the increased susceptibility to ocular infection seen in this group.

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Accession: 047321904

Download citation: RISBibTeXText

PMID: 10484197

DOI: 10.1046/j.1440-1606.1999.00206.x

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