+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Serological diagnosis of syphilis. PHLS Syphilis Serology Working Group

Serological diagnosis of syphilis. PHLS Syphilis Serology Working Group

Communicable Disease and Public Health 3(3): 158-162

The availability of an increasing number of enzyme immunoassays (EIAs) for detecting syphilis antibodies makes it appropriate to review approaches to syphilis serology and to assess the role of syphilis EIAs in routine diagnostic microbiology laboratories. This paper summarises the principles and practice of syphilis serology and provides recommendations on the use of laboratory tests for syphilis in UK diagnostic microbiology laboratories. The main recommendations are summarised in a testing algorithm. Treponemal EIAs are an appropriate alternative to the use of combined Venereal Disease Research Laboratories/rapid plasma reagin and Treponema pallidum haemagglutination assay (TPHA) tests for screening for syphilis. If a treponemal EIA is used for screening an alternative treponemal test, such as TPHA, should be used for confirmatory testing. The fluorescent treponemal antibody-absorbed test is probably best reserved for specimens giving discrepant results. Such specimens may be referred to the PHLS laboratories that provide confirmatory treponemal testing for reference testing and to facilitate collection of surveillance data on what remains an important public health problem.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 047342932

Download citation: RISBibTeXText

PMID: 11014025

Related references

Comparison of ortho diagnostic systems inc syphilis g and syphilis m antibody elisa test with conventional serological methods for diagnosis of congenital syphilis. Abstracts of the Annual Meeting of the American Society for Microbiology 90: 362, 1990

Syphilis serology. Its aids and limitations in the diagnosis of syphilis. Nova Scotia Medical Bulletin 51(2): 36-40, 1972

A new recombinant antigen latex agglutination test (Syphilis Fast) for the rapid serological diagnosis of syphilis. International Journal of Std & Aids 9(4): 196-200, 1998

Syphilis fast Usefulness of a recombinant antigen latex agglutination test for the rapid serological diagnosis of syphilis. International Journal of STD & AIDS 12(Suppl. 2): 141, 2001

The modern serology of syphilis part 2 the large scale preparation of a cardio lipin antigen of the venereal disease research laboratory type for the diagnosis of syphilis by flocculation reaction value and techniques of use. Microbiologia Parazitologia Epidemiologia 16(3): 263-272, 1971

Use of the INNO-LIA syphilis score assay in the resolution of discordant positive screening enzyme immunoassay results for the serological diagnosis of syphilis. International Journal of Std and Aids 25(1): 52-56, 2014

Comparative evaluation of the INNO-LIA syphilis score and the MarDx Treponema pallidum immunoglobulin G Marblot test assays for the serological diagnosis of syphilis. International Journal of Std and Aids 21(2): 110-113, 2010

Standardization of working conditions in serological laboratories - a way to optimization of laboratory diagnosis of syphilis. Vestnik Dermatologii i Venerologii (6): 28-32,33, 2007

P5.089Confirmation of High Specificity of an Automated Elisa Test For Serological Diagnosis of Syphilis - Results from Confirmatory Testing After Syphilis Screening and Sensitivity Analysis in the Absence of a Gold Standard. Sexually Transmitted Infections 89(Suppl 1): A362.3-A363, 2013

The decentralization of syphilis screening for improved care in Jamaican public clinics. Collaborative Working Group on Decentralized Syphilis Screening. American Journal of Public Health 87(6): 1019-1021, 1997

Comparative research on the value of the "Behringwerke rapid syphilis test" using inactivated serum. With a remark on Fuehner's "whole serological picture" and on the erroneous theoretical evaluation of syphilis serological findings. Der Hautarzt; Zeitschrift für Dermatologie Venerologie und verwandte Gebiete 12: 221-230, 1961

The value of disregarding the number of years. Blood and cerebrospinal fluid syphilis serology: gummatous syphilis. Revue Neurologique 165 Spec no 1: F28 F30, 2009

Lupus nephropathy with positive syphilis serology, difficult differentiation from renal involvement in syphilis. Anales de Medicina Interna 7(12): 651-652, 1990

Quantitative serology and syphilis; serologic follow-up on patients treated for syphilis by a short intensive method. Journal of the Indiana State Medical Association 41(5): 513, 1948

Syphilis serology in patients with primary syphilis and non-treponemal sexually transmitted diseases in southern Africa. Genitourinary Medicine 67(2): 129-132, 1991