EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Stretch-induced changes in heart rate and rhythm: clinical observations, experiments and mathematical models


Progress in Biophysics and Molecular Biology 71(1): 91-138
Stretch-induced changes in heart rate and rhythm: clinical observations, experiments and mathematical models
Clinical and research data indicate that active and passive changes in the mechanical environment of the heart are capable of influencing both the initiation and the spread of cardiac excitation via pathways that are intrinsic to the heart. This direction of the cross-talk between cardiac electrical and mechanical activity is referred to as mechano-electric feedback (MEF). MEF is thought to be involved in the adjustment of heart rate to changes in mechanical load and would help to explain the precise beat-to-beat regulation of cardiac performance as it occurs even in the recently transplanted (and, thus, denervated) heart. Furthermore, there is clinical evidence that MEF may be involved in mechanical initiation of arrhythmias and fibrillation, as well as in the re-setting of disturbed heart rhythm by 'mechanical' first aid procedures. This review will outline the clinical relevance of cardiac MEF, describe cellular correlates to the responses observed in situ, and discuss the role that quantitative mathematical models may play in identifying the involvement of cardiac MEF in the regulation of heart rate and rhythm.


Accession: 047449275

PMID: 10070213

DOI: 10.1016/s0079-6107(98)00038-8



Related references

Strecht-induced changes in heart rate and rhythm Clinical observations, experiments and mathematical models. Progress in Biophysics & Molecular Biology 71(1): 91-138, Jan, 1999

Cybernetics in cardiology Mathematical models of the heart rhythm and their diagnostic significance. 1967

From biological and clinical experiments to mathematical models. Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences 367(1908): 4657-4663, 2010

Chronic kidney disease in patients with cardiac rhythm disturbances or implantable electrical devices: clinical significance and implications for decision making-a position paper of the European Heart Rhythm Association endorsed by the Heart Rhythm Society and the Asia Pacific Heart Rhythm Society. Europace 17(8): 1169-1196, 2016

Stretch-induced voltage changes in the isolated beating heart: importance of the timing of stretch and implications for stretch-activated ion channels. Cardiovascular Research 32(1): 120-130, 1996

Mathematical models for heart rate responses to vagal nerve stimulation. Dissertation Abstracts International B Sciences & Engineering 32(9): 5156-B-5157-B, 1972

Amplitude and polarity of stretch-induced systolic and diastolic voltage changes depend on the timing of stretch A means to characterize stretch-activated channels in the intact heart. European Heart Journal 14(ABSTR SUPPL ): 39, 1993

Circadian rhythm of the corrected QT interval: impact of different heart rate correction models. Pacing and Clinical Electrophysiology 26(1 Pt 2): 383-386, 2003

A broken heart: a stretch too far: an overview of mouse models with mutations in stretch-sensor components. International Journal of Cardiology 131(1): 33-44, 2008

Advances in heart rate variability signal analysis: joint position statement by the e-Cardiology ESC Working Group and the European Heart Rhythm Association co-endorsed by the Asia Pacific Heart Rhythm Society. Europace 17(9): 1341-1353, 2016