+ Translate

Stretch-induced changes in heart rate and rhythm: clinical observations, experiments and mathematical models

, : Stretch-induced changes in heart rate and rhythm: clinical observations, experiments and mathematical models. Progress in Biophysics and Molecular Biology 71(1): 91-138

Clinical and research data indicate that active and passive changes in the mechanical environment of the heart are capable of influencing both the initiation and the spread of cardiac excitation via pathways that are intrinsic to the heart. This direction of the cross-talk between cardiac electrical and mechanical activity is referred to as mechano-electric feedback (MEF). MEF is thought to be involved in the adjustment of heart rate to changes in mechanical load and would help to explain the precise beat-to-beat regulation of cardiac performance as it occurs even in the recently transplanted (and, thus, denervated) heart. Furthermore, there is clinical evidence that MEF may be involved in mechanical initiation of arrhythmias and fibrillation, as well as in the re-setting of disturbed heart rhythm by 'mechanical' first aid procedures. This review will outline the clinical relevance of cardiac MEF, describe cellular correlates to the responses observed in situ, and discuss the role that quantitative mathematical models may play in identifying the involvement of cardiac MEF in the regulation of heart rate and rhythm.

(PDF 0-2 workdays service)

Accession: 047449275

PMID: 10070213

Submit PDF Full Text: Here

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Related references

Kohl, P.; Hunter, P.; Noble, D., 1999: Strecht-induced changes in heart rate and rhythm Clinical observations, experiments and mathematical models. Progress in Biophysics & Molecular Biology 71(1): 91-138, Jan

Anonymous, 1967: Cybernetics in cardiology Mathematical models of the heart rhythm and their diagnostic significance

Demongeot, J.; Françoise, J-Pierre.; Nerini, D., 2010: From biological and clinical experiments to mathematical models. Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences 367(1908): 4657-4663

Boriani, G.; Savelieva, I.; Dan, G-Andrei.; Deharo, J.Claude.; Ferro, C.; Israel, C.W.; Lane, D.A.; L.M.nna, G.; Morton, J.; Mitjans, A.Moya.; Vos, M.A.; Turakhia, M.P.; Lip, G.Y.H.; Gorenek, B.; Takahashi, Y.; Lau, D.; Chung, M.; Nielsen, J.Cosedis.; Fauchier, L.; Potpara, T.; Marin, F.; Kudaiberdieva, G.; Hindricks, G.; Linde, C.; Brignole, M., 2016: Chronic kidney disease in patients with cardiac rhythm disturbances or implantable electrical devices: clinical significance and implications for decision making-a position paper of the European Heart Rhythm Association endorsed by the Heart Rhythm Society and the Asia Pacific Heart Rhythm Society. Europace 17(8): 1169-1196

Zabel, M.; Koller, B.S.; Sachs, F.; Franz, M.R., 1996: Stretch-induced voltage changes in the isolated beating heart: importance of the timing of stretch and implications for stretch-activated ion channels. Objectives: It is now well recognized that myocardial stretch can cause arrhythmias due to stretch-induced depolarizations. The effects of transient stretch applied during the various phases of the cardiac action potential have not been investigat...

Glaze H.J.Jr, 1972: Mathematical models for heart rate responses to vagal nerve stimulation. Dissertation Abstracts International B Sciences & Engineering 32(9): 5156-B-5157-B

Zabel, M.; Koller, B.; Franz, M.R., 1993: Amplitude and polarity of stretch-induced systolic and diastolic voltage changes depend on the timing of stretch A means to characterize stretch-activated channels in the intact heart. European Heart Journal 14(ABSTR SUPPL ): 39

Smetana, P.; Batchvarov, V.; Hnatkova, K.; Camm, A.John.; Malik, M., 2003: Circadian rhythm of the corrected QT interval: impact of different heart rate correction models. A reduced circadian pattern in the QTc interval has been repeatedly reported to provide prognostic information in cardiac patients. However, the results of studies in healthy subjects in which different heart rate correction formulas were used are...

Cox, L.; Umans, L.; Cornelis, F.; Huylebroeck, D.; Zwijsen, A., 2008: A broken heart: a stretch too far: an overview of mouse models with mutations in stretch-sensor components. With every heartbeat the heart must contract and relax. This seemingly trivial process critically needs tight control of contraction and relaxation phases, and extremely efficient coordination between these two phases to control blood flow and mai...

Sassi, R.; Cerutti, S.; Lombardi, F.; Malik, M.; Huikuri, H.V.; Peng, C-Kang.; Schmidt, G.; Yamamoto, Y., 2016: Advances in heart rate variability signal analysis: joint position statement by the e-Cardiology ESC Working Group and the European Heart Rhythm Association co-endorsed by the Asia Pacific Heart Rhythm Society. Following the publication of the Task Force document on heart rate variability (HRV) in 1996, a number of articles have been published to describe new HRV methodologies and their application in different physiological and clinical studies. This do...