EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Structures of withanosides I, II, III, IV, V, VI, and VII, new withanolide glycosides, from the roots of Indian Withania somnifera DUNAL. and inhibitory activity for tachyphylaxis to clonidine in isolated guinea-pig ileum


Structures of withanosides I, II, III, IV, V, VI, and VII, new withanolide glycosides, from the roots of Indian Withania somnifera DUNAL. and inhibitory activity for tachyphylaxis to clonidine in isolated guinea-pig ileum



Bioorganic and Medicinal Chemistry 9(6): 1499-1507



ISSN/ISBN: 0968-0896

PMID: 11408168

DOI: 10.1016/s0968-0896(01)00024-4

Seven new withanolide glycosides called withanosides I, II, III, IV, V, VI, and VII were isolated from an Indian natural medicine, Ashwagandha, the roots of Indian Withania somnifera DUNAL. (Solanaceae), together with four known compounds, withaferin A, 5 alpha,20 alpha(F)(R)-dihydroxy-6 alpha,7 alpha-epoxy-1-oxowitha-2,24-dienolide, physagulin D, and coagulin Q. The structures of withanosides I, II, III, IV, V, VI, and VII were determined based on chemical and physicochemical evidence. Principal constituents, withanoside VI (10 and 30 microM) and withaferin A (10 microM), attenuated the tachyphylaxis to clonidine on electrically stimulated guinea-pig ileum in vitro.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 047459948

Download citation: RISBibTeXText

Related references

Evaluation of Withanolide-A and Withaferin-A in Withania somnifera Dunal roots from different climatic zones of Madhya Pradesh. Indian Journal Of Tropical Biodiversity: 2, 152-154, 2008

Carbon sources and medium pH affects the growth of Withania somnifera (L.) Dunal adventitious roots and withanolide A production. Natural Product Research 27(2): 185-189, 2013

Evaluation of Withanolide-A and Withaferin-A in Withania somnifera (L.) Dunal (Ashwagandha) roots from different climatic zones of Madhya Pradesh. Indian Journal of Tropical Biodiversity 15(2): 152-154, 2008

Metabolic clustering of a core collection of Indian ginseng Withania somnifera Dunal through DNA, isoenzyme, polypeptide and withanolide profile diversity. Fitoterapia 80(8): 496-505, 2009

Structural Characterization of Withanolide Glycosides from the Roots of Withania somnifera and their Potential Biological Activities. Plants 11(6), 2022

Estimation of withanolide-A in diverse genotypes of Ashwagandha Withania somnifera (L.) Dunal. Indian Journal of Experimental Biology 57(3): 212-217, 2019

Drug yield and withanolide contents of Withania somnifera (L.) Dunal cultivated in Turkey. Acta Horticulturae 306: 219-228, 1992

Nanoparticles alter the withanolide biosynthesis and carbohydrate metabolism in Withania somnifera (Dunal). Industrial Crops and Products 127: 94-109, 2019

Molecular characterization ofDWF1from Withania somnifera(L.) Dunal: its implications in withanolide biosynthesis. Journal of Plant Biochemistry and Biotechnology 26(1): 52-63, 2017

Drug yields and withanolide contents of withania somnifera dunal cultivated in turkiye. Gazi Universitesi Eczacilik Fakultesi Dergisi 8(2): 89-100, 1991

Fungal endophytes attune withanolide biosynthesis in Withania somnifera, prime to enhanced withanolide A content in leaves and roots. World Journal of Microbiology and Biotechnology 35(2): 20, 2019

Adaptogenic activity of a novel, withanolide-free aqueous fraction from the roots of Withania somnifera Dun. PhytoTherapy Research: Ptr 15(4): 311-318, 2001

Elicitation Approaches for Withanolide Production in Hairy Root Culture of Withania somnifera (L.) Dunal. Methods in Molecular Biology 1405: 1-18, 2016

Further studies on adaptogenic activity of withanolide-free hydrosolubel fraction from the roots of Withania somnifera DUN. Indian Journal of Pharmacology 34(2): 152, 2002

Adaptogenic activity of a novel withanolide-free aqueous fraction from the roots of Withania somnifera Dun. (Part II). PhytoTherapy Research: Ptr 17(5): 531-536, 2003