Synthesis of Dolastatin 15 mimetic peptoids
Schmitt, J.; Bernd, M.; Kutscher, B.; Kessler, H.
Bioorganic and Medicinal Chemistry Letters 8(4): 385-388
1998
ISSN/ISBN: 0960-894X PMID: 9871690 DOI: 10.1016/s0960-894x(98)00034-1
Accession: 047514225
Eight peptoids have been synthesized as peptidomimetics of the cytostatic Dolastatin 15, a depsipeptide isolated from the Indian sea hare Dolabella auricularia. The compounds have been tested against several human cancer cell lines and did not show any cytostatic properties.
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