+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Tedisamil (Solvay)



Tedisamil (Solvay)



Current Opinion in Investigational Drugs 2(1): 97



Tedisamil, a potassium channel blocker (class III anti-arrhythmic agent)from Solvay, is in phase II trials for the potential treatment of atrial fibrillation [342434]. The drug had completed phase III trials for angina pectoris [342434], [177648], and although an NDA dossier for angina pectoris in refractory patients was ready for filing with the US FDA, Solvay has decided to pursue the broader indication of atrial fibrillation instead [342434]. Tedisamil is bradycardic without producing a negative inotropic effect. In a canine model of exercise-induced angina, myocardial function was maintained. In rat, rabbit, canine and simian hearts, there was a marked prolongation of action potential, due to tedisamil's modulating effects on potassium channels. Diastolic arterial pressure was not influenced [276934]. Tedisamil also rapidly terminated sustained atrial fibrillation and prevented its reinitiation in a canine model of the condition [315378]. The class III antiarrhythmic effect of tedisamil is related predominantly to the strong blocking effect of the drug on the rapid component of the delayed rectifier potassium current [334806].

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 047535751

Download citation: RISBibTeXText

PMID: 11527020


Related references

Discovering the fauna of the Solvay land A la decouverte de la faune du Domaine Solvay. Homme et l'Oiseau. avril-mai-juin; 442: 126-140, 2006

SLV-308. Solvay. Current Opinion in Investigational Drugs 4(7): 878-882, 2003

SLV-306. Solvay. Current Opinion in Investigational Drugs 4(3): 329-332, 2003

Cilansetron. Solvay. Current Opinion in Investigational Drugs 2(10): 1432-1436, 2001

Solvay conference. Science 152(3720): 393, 1966

Solvay will take a harder look at biotechnology. Genetic Technology News 5(1): 9, 1985

The Solvay spoil mound.. Rev. Eaux For, 84: 11, 679-82, 1946

DU-127090 Solvay/H Lundbeck. Current Opinion in Investigational Drugs 4(1): 72-76, 2003

Magnetic treatment of solvay still waste. Chemical and Petroleum Engineering 6(3): 222-223, 1970

Proceedings of Solvay Chicken Health Course. 1992

Accessible designs in Solvay cluster synthesis. Chemical Engineering Science 31(8): 701-703, 1976

Development of Solvay clusters of chemical reactions. Chemical Engineering Science 31(1): 59-69, 1976

Group portraits IV the Seventh Solvay Conference. Endeavour 25(4): 137-138, 2001

The Solvay Quarry in Damparis, Jura Mountains. Mineraux et Fossiles, le Guide du Collectionneur: 01, Pages 35-37. 2001., 2001

La faune des libellules du domaine Solvay a La Hulpe. Naturalistes Belges 721: 31-39, 1991