+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The effect of bilateral removal of the submandibulary salivary glands on the erythropoietic response of mice



The effect of bilateral removal of the submandibulary salivary glands on the erythropoietic response of mice



Experimental Hematology 21(5): 656-659



The role of the submandibular salivary gland in erythropoiesis in the male mouse (MRC TO strain) was evaluated by subjecting mice without submandibular salivary glands (SX) and control (C) sham-operated mice to a variety of stimuli intended to stress the erythropoietic system. In SX mice, after removal of the submandibular glands at age 4 weeks and observation for 8 weeks, mean hematocrit was the same as in C mice, but mean body weight was less. Bilateral removal of the submandibular glands at age 6 weeks neither affected the rate of fall and subsequent recovery of hematocrit which followed treatment with phenylhydrazine (80 mg/kg intraperitoneally [i.p.] 9 days after operation) nor altered the rate of increase in hematocrit or change in body weight which occurred during hypobaric hypoxia (0.5 atm, > 23 hours/day) for 23 days. Mean (SEM) estimates of serum immunoreactive erythropoietin after 17 hours' continuous hypobaric (0.5 atm) exposure were not significantly different between SX [186 (30) mU/mL, n = 7] and C mice [232 (17) mU/mL, n = 7]. In mice given bilateral nephrectomies at age 6 weeks--2 weeks after SX or C surgery--and then both treated with phenylhydrazine (60 mg/kg i.p.) and exposed for 17 hours to hypobaric (0.5 atm) hypoxia, mean estimates of serum immunoreactive erythropoietin were 22.6 (10.6) mU/mL and 22.3 (5.4) mU/mL in SX (n = 5) and C (n = 5) mice. Results of the study do not support the premise that the submandibular salivary glands either contribute to the erythropoietic response or are a source of extrarenal erythropoietin.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 047617470

Download citation: RISBibTeXText

PMID: 8513866


Related references

The effect of bilateral spheno ethmoidectomy on methacholine sensitivity in patients with sinusitis and bronchial asthma. Journal of Allergy and Clinical Immunology 73(1 Part 2): 145, 1984

Removal of the submaxillary salivary glands and infection with the trematode Schistosoma mansoni alters exploratory behavior and pain thresholds in female mice. Physiology and Behavior. 62(2): 399-406, 1997

Influence of salivary gland hormone on the number of leukocytes and level of calcium in the blood of experimental rabbits. Eksperimentalna Meditsina i Morfologiia 16(3): 142-146, 1977

Inhibitory effect of azadirachtin on larval meat consumption and fecundity in myiasis producing flies. Indian Journal of Animal Sciences 73(7): 755-756, 2003

Effect of low-power laser irradiation on the structure and properties of protein molecules under non-specific energy absorbance. Fiziolohichnyi Zhurnal 49(2): 96-99, 2003

The effect of salivary gland extirpation duct ligation and thyroxine administration on the emergence time and eruption rate of teeth in rats. Revista de Odontologia da UNESP (Universidade Estadual Paulista) 14(1-2): 85-96, 1985

Bilateral removal of cholesteatoma. Archiv für Klinische und Experimentelle Ohren- Nasen- und Kehlkopfheilkunde 194(2): 642-645, 1969

The action of the dihydro derivatives of prostacyclin--(6R)-PGI1 and (6S)-PGI1 on the heart and the coronary vasculature. Naunyn-Schmiedeberg's Archives of Pharmacology 306(3): 213-217, 1979

Histological studies on monkeys experimentally infected with anisakis larvae. Chinese Journal of Microbiology 3(1-2): 29-41, 1970

Histofluorescence characteristics and quantification of small intensely fluorescent (SIF) cells in sympathetic ganglia of several species. Cell and Tissue Research 162(3): 331-341, 1975

Effect of IBA and different types of cutting on vegetative propagation of the Acca sellowiana Berg. Revista Brasileira de Agrociencia 10(4): 515-518, 2004

Effect of Lactobacillus sakei Lb706 on behavior of Listeria monocytogenes in vacuum-packed rainbow trout fillets. Turk Veterinerlik ve Hayvanclk Dergisi 29(4): 1039-1044, 2005

Studies on the physiological chemistry of the salivary glands XLV Size and shape determination of saliva-parotin-A in buffers of various hydrogen ion concentrations. Endocrinologia Japonica 7(2): 146-152, 1960

Studies on the physiological chemistry of the salivary glands. 45. Size and shape determination of saliva-parotin-A in buffers of various hydrogen ion concentrations. Endocrinologia Japonica 7: 146-152, 1960

On the functional correlation between salivary glands and other endocrine organs. III. The relationship between iodine metabolism by the thyroid gland and the weight of the salivary glands of rats. (Studies on the physiological chemistry of the salivary glands. L). Endocrinologia Japonica 8: 1-8, 1961