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The effect of dexamethasone upon patient-controlled analgesia-related nausea and vomiting



The effect of dexamethasone upon patient-controlled analgesia-related nausea and vomiting



Anaesthesia 57(7): 705-709



Ninety female patients were enrolled in this randomised, double-blind, placebo-controlled study to compare the anti-emetic effect of intravenous dexamethasone 8 mg with saline control in preventing patient-controlled analgesia-related nausea and vomiting following major orthopaedic surgery. The prophylactic administration of dexamethasone 8 mg significantly reduced the overall incidence of patient-controlled analgesia-related nausea and vomiting (p<0.001) and the need for rescue anti-emetics (p<0.01). Furthermore, patients who received dexamethasone showed a higher incidence of complete responses (no vomiting or need for rescue anti-emetic for a 24-h postoperative period) than those who received saline (p<0.05). We conclude that dexamethasone 8 mg may be valuable for preventing patient-controlled analgesia-related nausea and vomiting in women undergoing major orthopaedic surgery.

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Accession: 047618901

Download citation: RISBibTeXText

PMID: 12109416

DOI: 10.1046/j.1365-2044.2002.02572_5.x


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