+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The effect of dexrazoxane (ICRF-187) on doxorubicin- and daunorubicin-mediated growth inhibition of Chinese hamster ovary cells



The effect of dexrazoxane (ICRF-187) on doxorubicin- and daunorubicin-mediated growth inhibition of Chinese hamster ovary cells



Anti-Cancer Drugs 7(5): 558-567



Dexrazoxane (ICRF-187) is clinically used to reduce doxorubicin-induced cardiotoxicity. Because dexrazoxane, doxorubicin and daunorubicin all act on DNA topoisomerase II, a study was undertaken to see what effect dexrazoxane had on the growth inhibitory effects of doxorubicin and daunorubicin towards Chinese hamster ovary cells. Dexrazoxane exhibited significant antagonism of doxorubicin- and daunorubicin-mediated growth inhibition when the cells were preincubated with dexrazoxane before the anthracycline was added. Continuous exposure of cells to either anthracycline and low concentrations of dexrazoxane resulted in additive growth inhibitory effects at low anthracycline concentrations, and no effect at higher anthracycline concentrations.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 047618903

Download citation: RISBibTeXText

PMID: 8862724

DOI: 10.1097/00001813-199607000-00011


Related references

The cardioprotection of rutaecarpine is mediated by endogenous calcitonin related-gene peptide through activation of vanilloid receptors in guinea-pig hearts. Planta Medica 68(8): 705-709, 2002

The one-migrant-per-generation rule in conservation and management. Conservation Biology 10(6): 1509-1518, 1996

The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces differentiation and apoptosis in human leukemia K562 cells. Molecular Pharmacology 59(3): 453-461, 2001

Characterization of a Ca2+-activated K+ current in insulin-secreting murine betaTC-3 cells. Journal of Physiology 509: 355-370, 1998

Ethanol potentiates and blocks NMDA-activated single-channel currents in rat hippocampal pyramidal cells. Febs Letters 247(1): 61-67, 1989

Effect of doxofylline on calcium-activated potassium channels in human peripheral blood eosinophils in asthma. Zhonghua Jiehe He Huxi Zazhi 28(12): 817-819, 2005

The downy mildew fungus Peronospora sparsa in wild arctic bramble and in cultivated hybrid arctic bramble-sampling in northern Sweden. Vaxtskyddsnotiser 62(3): 41-45, 1998

Effect of pH and media on the incidence of Phoma medicaginis var. sojae in soybean seeds. Geobios (Jodhpur) 20(1): 33-35, 1993

Polyclonal antibody-induced serum sickness presenting as rapidly progressive descending paralysis. Transplantation 83(12): 1657, 2007

Effect of tauroursodeoxycholic and ursodeoxycholic acid on ethanol-induced cell injuries in the human hep G2 cell line. Gastroenterology. 109(2): 555-563, 1995

Influence of Hyostrongylus infection on plasma pepsinogen content and electrolyte concentration of gastric juice in the pig. Zentralblatt für Veterinarmedizin. Reihe B. Journal of Veterinary Medicine. Series B 19(5): 416-425, 1972

A comparative study of genotoxic effects in the treatment of trichomonas vaginalis infection: Metronidazole or nalidixic acid. Archives of Gynecology and Obstetrics 264(1): 20-23, 2000

Modification of dopamine release by selective inhibitors of MAO-B. Neurobiology 8(2): 137-142, 2000

Acetaldehyde levels in Asian men with different ALDH2 genotypes. Society for Neuroscience Abstracts 21(1-3): 1240, 1995

Inhibition of the growth cone H-current by clonidine in cultured rat dorsal root ganglion neurons. Society for Neuroscience Abstracts 24(1-2): 2089, 1998