The effect of subhypnotic doses of propofol on the incidence of pruritus after intrathecal morphine for caesarean section

Warwick, J.P.; Kearns, C.F.; Scott, W.E.

Anaesthesia 52(3): 270-275

1997


ISSN/ISBN: 0003-2409
PMID: 9124670
DOI: 10.1111/j.1365-2044.1997.069-az0060.x
Accession: 047625677

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Abstract
The effect of subhypnotic doses of propofol on intrathecal morphine-induced pruritus was studied in a prospective, randomly allocated, double-blind controlled trial. Fifty-eight women undergoing elective lower segment Caesarean section for a singleton fetus received spinal anaesthesia with 2.5 ml hyperbaric 0.5% bupivacaine and 0.2 mg of preservative-free morphine. They then received propofol 1 ml (10 mg) or Intralipid 1 ml (control group) intravenously after delivery. Pruritus was assessed using a five-point verbal rating scale at hourly intervals for 8 h. A second dose of their allocated treatment drug was administered at the first recording of significant pruritus. The pruritus score was reassessed after 5 min and the treatment was repeated if pruritus remained. There were no differences between the groups in the onset of pruritus or its successful treatment. No adverse side-effects were associated with this dose of propofol. There were no differences in the incidence of post-operative nausea and vomiting between the two groups. Subhypnotic propofol is not an effective treatment for intrathecal morphine-induced pruritus in women following Caesarean section.

The effect of subhypnotic doses of propofol on the incidence of pruritus after intrathecal morphine for caesarean section