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The effect of the spectrum fatty acids in plasma lipids on the hypolipidemic effect of fish oils in hyperlipidemic patients


The effect of the spectrum fatty acids in plasma lipids on the hypolipidemic effect of fish oils in hyperlipidemic patients



Vnitrni Lekarstvi 39(7): 682-689



ISSN/ISBN: 0042-773X

PMID: 8372464

The authors administered to a group of 60 patients with primary hyperlipoproteinaemia (HLP) HLP type IIA 9, IIB 16, type IV 35 (fish oil) (Activepa 30TG) rich in eicosapentaenic acid (EPA, 20:5-n-3) and docosahexaenic acid (DHA, 22:6n-3). Administration of fish oil, 10 g per day, for a period of 21 days led to a decline of the total cholesterol by 9.8%, triglycerides (TG) by 39.5% and a rise of HDL-cholesterol (HDL-C) by 12.8%. The concentration of LDL-C, apo B, and apo A-I did not change significantly. The content of individual fatty acids (FA) in phosphatidyl choline (PC) cholesteryl esters (CE) and plasma TG before treatment was used as an independent variable for discrimination analysis in relation to dependent variables such quintile 1 (Q1) and Q2 on the one hand and Q4 and Q5 differences of the above mentioned parameters on the other hand. The drop of TG after ingestion of n-3 FA correlates indirectly with concentrations of PC 20:5n-3, TG 18:3n-3 and TG 20:4n-6. The content of 20:0 and 20:1 in PC and 18:0 in TG are related to the rise of LDL-C after treatment. The drop of apo B is associated with the PC 22:6n-3 concentration. The rise of HDL-C and apo A-I is positively associated with the concentration of 16:1n-7 in PC and TG and negatively with the CE 16:0 content. The rise of HDL-C after treatment is moreover negatively influenced by concentrations of PC 18:3n-6 and TG 20:3n-6.

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