The effects of aprotinin. Blood loss and coagulation parameters in orthotopic liver transplantation: a clinical-experimental, prospective and randomized double-blind study

Kratzer, M.A.; Azad, S.C.; Groh, J.; Welte, M.; Haller, M.; Pratschke, E.

Der Anaesthesist 46(4): 294-302

1997


ISSN/ISBN: 0003-2417
PMID: 9229983
DOI: 10.1007/s001010050404
Accession: 047629283

Download citation:  
Text
  |  
BibTeX
  |  
RIS

Article/Abstract emailed within 0-6 h
Payments are secure & encrypted
Powered by Stripe
Powered by PayPal

Abstract
The effect of aprotinin (2,000,000 IU as a bolus +500,000 JU/h until the end of the operation) on transfusion requirements and coagulation parameters in orthotopic liver transplantation (study group: n = 9; placebo group: n = 9) was investigated in a randomised, double-blind study. Coagulation parameters were monitored intraoperatively using a mobile laboratory. In contrast to the published results, no effect on transfusion requirements could be demonstrated. However, aprotinin showed a positive effect on some coagulation parameters in the reperfusion phase. The mechanism appeared to be inhibition of the contact activation of the intrinsic system with less thrombin generation in the study group.

The effects of aprotinin. Blood loss and coagulation parameters in orthotopic liver transplantation: a clinical-experimental, prospective and randomized double-blind study