+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The influence of pre-radiation salivary flow rates and radiation dose on parotid salivary gland dysfunction in patients receiving radiotherapy for head and neck cancers



The influence of pre-radiation salivary flow rates and radiation dose on parotid salivary gland dysfunction in patients receiving radiotherapy for head and neck cancers



Special Care in Dentistry 18(3): 102-108



Radiotherapy (RT) used for head and neck cancers causes permanent salivary gland dysfunction (SGD). Previous short-term studies have demonstrated that pre-RT salivary flow rates and the amount of radiation exposure to parotid glands influence the amount of RT-induced SGD. The purpose of this study was to determine which variables are related to the development of long-term post-RT SGD. Parotid flow rates (PFR) were assessed prior to and 1 year after completion of RT in spared parotid glands from 34 patients from 2 parotid-sparing protocols. The results reveal that spared PFR were not significantly higher 1 year post-RT in patients who had high pre-RT PFR, when compared with patients with low pre-RT PFR. However, patients who received higher doses of RT to spared parotid glands had lower PFR 1 year post-RT, compared with patients who had received lower doses of RT. These one-year findings suggest that high pre-RT PFR do not provide protection against RT-induced SGD. Conversely, reduced RT dosages to contralateral parotid glands are protective of PFR after completion of RT.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 047666789

Download citation: RISBibTeXText

PMID: 9680919

DOI: 10.1111/j.1754-4505.1998.tb00913.x


Related references

Two-year longitudinal study of parotid salivary flow rates in head and neck cancer patients receiving unilateral neck parotid-sparing radiotherapy treatment. Oral Oncology 35(3): 234-241, 1999

Salivary flow rates measured during radiation therapy in head and neck cancer patients: a pilot study assessing salivary sediment formation. Journal of Prosthetic Dentistry 100(2): 142-146, 2008

Recovery kinetics of salivary function in patients with head and neck cancers receiving radiation therapy. International Journal of Radiation Oncology Biology Physics 54(2 Suppl.): 166, 2002

The impact of dose on parotid salivary recovery in head and neck cancer patients treated with radiation therapy. International Journal of Radiation Oncology Biology Physics 67(3): 660-669, 2007

Functional outcome of parotid gland sparing in patients with head and neck cancers receiving intensity-modulated or 3-D radiation therapy. International Journal of Radiation Oncology Biology Physics 48(3 Suppl.): 174, 2000

Dose-volume modeling of salivary function in patients with head and neck cancer receiving radiation therapy. International Journal of Radiation Oncology*biology*physics 60: S189-S189, 2004

Functional outcome of parotid gland sparing in patients with head and neck (H&N) cancers receiving intensity-modulated (IMRT) or 3-D radiation therapy. International Journal of Radiation Oncology*biology*physics 48(3-Supp-S1): 174-0, 2000

A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy: Initial results. International Journal of Radiation Oncology Biology Physics 49(4): 907-916, 2001

Analysis of salivary flow and dose-volume modeling of complication incidence in patients with head-and-neck cancer receiving intensity-modulated radiotherapy. International Journal of Radiation Oncology Biology Physics 73(4): 1252-1259, 2009

A Novel Modeling for Salivary Toxicity Based on Salivary Flow Recovery Over Time in Head-and-Neck Cancer Patients Treated With Radiation Therapy. International Journal of Radiation Oncology*biology*physics 84(3): S503-S504, 2012

Influence of the Radiation Dose to Salivary Glands on Xerostomia in Patients with Head and Neck Carcinomas. Journal of Cancer Therapy 04(01): 188-194, 2013

Double blind randomized prospective trial of bethanechol in the prevention of radiation-induced salivary gland dysfunction in head and neck cancer patients. RadioTherapy and Oncology 115(2): 253-256, 2015

The utility of SPECT in determining the relationship between radiation dose and salivary gland dysfunction after radiotherapy. Nuclear Medicine Communications 22(2): 225-231, 2001

Preserved salivary output and xerostomia-related quality of life in head and neck cancer patients receiving parotid-sparing radiotherapy. Oral Oncology 37(1): 84-93, 2001

Changes in salivary gland function after radiotherapy of head and neck tumors measured by quantitative pertechnetate scintigraphy: comparison of intensity-modulated radiotherapy and conventional radiation therapy with and without Amifostine. International Journal of Radiation Oncology Biology Physics 67(3): 651-659, 2007