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The physiological function of plasma apoA-I--the anti-viral effects of apoA-I and its fragments



The physiological function of plasma apoA-I--the anti-viral effects of apoA-I and its fragments



Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae 16(2): 98-103



Apolipoprotein A-I (apoA-I), the major protein of plasma high density lipoproteins, was found to inhibit herpes simplex virus type I (HSV-I) induced cell fusion at physiological concentrations (mumol/L). Plasma apoA-I from three different species was used to study the anti-viral effects by microneutralization test. Marked inhibition of virus-induced cell fusion was observed when the virus or the cells were pretreated with apoA-I, suggesting that apoA-I may have a direct effect on the virus and the cells. This function may be related to the structure of apoA-I.

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Accession: 047699604

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PMID: 7987949


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