The receptor-mediated endocytosis of complexes of colloidal gold with high-density lipoproteins by the sinusoidal cells of the isolated rat liver

Pravotorov, G.V.; Usynin, I.F.; Poliakov, L.M.; Glazyrin, A.L.

Tsitologiia 35(11-12): 42-45


ISSN/ISBN: 0041-3771
PMID: 8009641
Accession: 047713296

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Rat hepatic sinusoidal cells absorption of native high-density lipoproteins was studied by electron microscope. Visualization of the endocytosis process was achieved by binding of lipoprotein particles and colloidal gold. The study was carried out on isolated liver perfusing by oxygenated nutritional media which consist of colloidal gold-lipoproteins conjugates. Electron microscope analysis testifies that high-density lipoproteins are absorbed by hepatic sinusoidal cells by means of receptor endocytosis. Both Kupffer cells and endothelial cells have such receptors. Lipoproteins of this class reach hepatic cells in Disse's space through the endothelium, i.e. transcellularly unlike low-density lipoproteins which penetrate paracellularly--through the fenestrae and intracellular contact's ares.